This proposal addresses the need for a commercially available turnkey USgFUS platform for research. Our hypothesis is that in less than a year, we can substantially augment our current hardware and software to provide a complete system for 3D therapy planning, delivery, and monitoring using ultrasound in a preclinical research context. We hypothesize that using a sequence of 2D visualizations and planning tools presented in a 3D framework, a user will be able to plan, treat, and monitor therapy progression for many preclinical targets of practical interest. Finally, we expect that at the end of the project and within a year, an evaluation of the platform in collaboration with FUSF and a preclinical research laboratory will be conducted
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