Focused ultrasound (FUS) has recently been demonstrated to have the efficacy and
safety for selective
targeting of deep-seated regions of the brain (Elias WJ et al.). The objective of the
program is to utilize FUS to target and treat deep-seated cerebral cavernous
malformations (CCM) in a mouse model of the disease. To accomplish this, we will
generate models of CCM using conditional deletion of the three genes responsible for
the human disease in an endothelial selective manner and utilize FUS to target these
lesions. If FUS can be safely used to target deep-seated vascular lesions, and if this
technology proves efficacious in treating
CCMs, it would provide a minimally invasive modality for treatment of a common and
devastating cause of stroke in the young.
No reports found.