Focused ultrasound for treatment of deep-seated cerebral cavernous malformations

Project Name: Focused ultrasound for treatment of deep-seated cerebral cavernous malformations
Status: Closed
Primary Site: University of Virginia Health System
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Mar 26, 2018
Funding Period: Mar 26, 2018 - Sep 24, 2019
Funding Program: Brain Program
Category: Pre-Clinical
Amount Awarded: $93,406.20


Focused ultrasound (FUS) has recently been demonstrated to have the efficacy and safety for selective targeting of deep-seated regions of the brain (Elias WJ et al.). The objective of the proposed research program is to utilize FUS to target and treat deep-seated cerebral cavernous malformations (CCM) in a mouse model of the disease. To accomplish this, we will generate models of CCM using conditional deletion of the three genes responsible for the human disease in an endothelial selective manner and utilize FUS to target these lesions. If FUS can be safely used to target deep-seated vascular lesions, and if this technology proves efficacious in treating CCMs, it would provide a minimally invasive modality for treatment of a common and devastating cause of stroke in the young.

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