We propose to refine our nonlinear model for simulating volumetric thermal lesions in tissue, optimize strategies for generating thermal lesions using electronic and mechanical translation of the focus, and experimentally validate the results in tissue phantoms and ex vivo tissue. Simulations and experiments will be performed for a multi-element phased array of a clinical MR-HIFU system (Sonalleve V2, Philips, Vantaa, Finland) that has been recently installed at the UW. This system's HIFU transducer is a 256-element array with 0.8-1.5 MHz frequency range, 140 mm focal length, 135.9 mm aperture, and F-number of 1.03. Thorough characterization of nonlinear fields generated by this transducer array, in particular when operating in shock-forming conditions, has not been done previously and is included in the proposed effort
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