Histotripsy is an ultrasound therapy that relies on the generation of cavitation bubble clouds to achieve therapeutic effect and has been shown to be able to generate targeted bubble clouds transcranially. Methods to monitor and localize the generated bubble clouds in real time need to be developed, however, to ensure that transcranial treatments can be delivered safely. Using signals from therapy pulses backscattered by histotripsy-generated bubble clouds and reflected by the skull, methods will be developed to localize and map histotripsy treatments through the skull, and to 3D map the skull surface for coregistration with prior scans, in real-time during therapy. These techniques have the potential to allow for targeting localization and treatment monitoring and mapping of histotripsy brain treatments through the skull in real-time without requiring MRI.
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