Patterning of bone regeneration via ultrasound activation of heat shock- responsive gene switches

Project Name: Patterning of bone regeneration via ultrasound activation of heat shock- responsive gene switches
Status: Complete
Primary Site: University of Michigan
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Mar 01, 2017
Funding Program: Research Award
Funding Period: Mar 01, 2017 - Feb 28, 2018
Amount Awarded: $100,000.00

Abstract

Bone loss due to trauma, neoplasia, or congential defects is a major worldwide problem. Current treatment options, such as bone grafting, are grossly inadequate because they offer no real control over the regenerative process. As an alternative, we propose to use focused ultrasound in combination with cells containing heat-activated gene switches to control expression of angiogenic and osteogenic factors. In this way, spatial and temporal control of growth factor release is achieved, thereby more closely mimicking endogenous bone regeneration. These proof-of-concept studies are aimed at demonstrating in vivo efficacy of this unique, potentially paradigm-changing therapeutic approach

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