Acoustic Parameters of Bone as a function of HU and MRI

Project Name: Acoustic Parameters of Bone as a function of HU and MRI
Status: Complete
Primary Site: Stanford University School of Medicine
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Feb 20, 2017
Funding Period: Feb 20, 2017 - Feb 21, 2018
Funding Program: Brain Program
Category: Technical
Amount Awarded: $100,072.00


Applications of focused ultrasound to the brain rely on the knowledge of acoustic parameters of bone, including the speed of sound, absorption, scattering, and heat capacity. The speed of sound is needed for phase aberration correction. The other parameters are needed for modeling of the loss when the beam crosses the skull, as well as modeling of heating in the skull. Phase aberration correction and accurate modeling are needed for all brain studies including ablation studies, BBB opening studies, and neuromodulation. Unfortunately, the literature on these values is scarce. They are sometimes given as a function of density and/or CT Hounsfield units, but this literature is not robust. They are never given as a function of MRI T2. This is needed for applications such as neuromodulation, as these studies need to rely on the less invasive MRI for phase aberration correction, rather than the more invasive CT. In this work, we propose to measure the acoustic parameters of bone as a function of CT HU and MRI UTE parameters and do a comparison with experimental effeciency of the skull in patients treated with ET.

Contact Roles


No reports found.

The Focused Ultrasound Foundation Newsletter

Our newsletter delivers updates for clinicians, researchers and patients. Sign up and stay on top of the rapid advancements of this innovative medical technology.

Sign Up  Read the Latest Issue

Read The Tumor  by John Grisham

From John Grisham, comes a story where today’s medical fiction could become tomorrow’s lifesaving reality.

Download a Free eBook or Audiobook

Contact Details

Call Us
Find Us
Focused Ultrasound Foundation
1230 Cedars Court, Suite 206 Charlottesville, VA 22903
Whitelist Instructions