Focused Ultrasound to Enhance Immunotherapy for Metastatic Brain Melanoma

Project Name: Focused Ultrasound to Enhance Immunotherapy for Metastatic Brain Melanoma
Status: Closed
Primary Site: Columbia University
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: May 05, 2017
Funding Period: May 05, 2017 - May 05, 2019
Funding Program: Immunotherapy
Category: Pre-Clinical
Amount Awarded: $100,000.00


We hypothesize that the integrity of the blood brain barrier (BBB) limits the penetration of the checkpoint inhibitor targeted therapy, anti- PD-1 antibody, thereby restricting the immune response and the abscopal effect for intracranial metastatic melanoma. Mechanical disruption of the BBB with focused ultrasound (FUS) with microbubbles can allow for great drug penetration and enhance the immune response. The addition of stereotactic radiosurgery (SRS) and immunotherapy with FUS will result in in situ tumor vaccination effects resulting in intracranial protection from new intracranial metastatic seeding.

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