Focused Ultrasound Treatment of Cerebral Cavernous Malformations

Project Name: Focused Ultrasound Treatment of Cerebral Cavernous Malformations
Status: Active
Primary Site: University of Virginia Health System
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: May 05, 2020
Funding Program: Brain Program
Funding Period: May 05, 2020 - May 05, 2021
Amount Awarded: $99,944.75

Abstract

The objective of the proposed research is to utilize Focused Ultrasound (FUS) to target and treat cerebral cavernous malformations (CCM) in a mouse model of the disease. To accomplish this, we will generate mice harboring CCM by conditional deletion of the genes responsible for the pathology (Krit1/Ccm1 and Ccm2/Malcavernin) in endothelial cells, and utilize FUS in conjunction with 5-Aminolevulinic acid (5-ALA) to target the malformations. If FUS can be safely used to target the vascular lesions, and if the treatment proves efficacious, it would provide a minimally invasive modality for treatment of a common and devastating disease in the young.

Contact Roles

Reports

No reports found.

The Focused Ultrasound Foundation Newsletter

Our newsletter delivers updates for clinicians, researchers and patients. Sign up and stay on top of the rapid advancements of this innovative medical technology.

Sign Up  Read the Latest Issue

Read The Tumor  by John Grisham

From John Grisham, comes a story where today’s medical fiction could become tomorrow’s lifesaving reality.

Download a Free eBook or Audiobook

Contact Details

Call Us
434.220.4993
Find Us
Focused Ultrasound Foundation
1230 Cedars Court, Suite 206 Charlottesville, VA 22903
Email