Foundation Funded Research Projects

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Showing 100 out of 195 research projects

Category	Research Question	Project Name (Click on the project name for more info)	Primary Research Site	Principal Investigator	Funding Dates	Program
Technical		Development of a transcranial sonication efficiency estimation toolkit	Jeju National University	Dong-Guk Paeng	Mar 01, 2021 - Feb 28, 2023
Clinical Research	Will opening the BBB with the NaviFUS device in patients with GBM combined with Avastin therapy improve their outcomes?	An open label, prospective, pilot study to evaluate the efficacy and safety of best physician’s choice of standard of care combined with or without N...	Chang Gung Memorial Hospital, Taoyuan	Kuo-Chen Wei	Dec 21, 2020 - Dec 20, 2021	Brain Program
Vet	Can histotripsy safely treat brain tumors in dogs?	Ultrasound-guided histotripsy ablation of spontaneous brain tumors in canines through a cranial window	Virginia Polytechnic Institute and State University	Eli Vlaisavljevich	Dec 01, 2020 - Dec 01, 2021	Veterinary
Pre-Clinical	Can FUS plasmid delivery enhance gene expression?	Enhancing Neurogenesis by Focused Ultrasound-mediated Plasmid Delivery	University of Virginia Health System	Petr Tvrdik	Nov 06, 2020 - Nov 05, 2021	Research Award
Technical	What is the appropriate metric by which to report dose for histotripsy sonications?	Real-time Transcranial Histotripsy Dose Monitoring via Acoustic Cavitation Emission (ACE) Feedback Methods	University of Michigan	Jonathan Sukovich	Oct 13, 2020 - Oct 12, 2021	Brain Program
Clinical Research	Will FUS treatment of pancreatic cancer impact the anti-tumor immune response and improve survival?	A Phase I Study of Magnetic Resonance Guided High Intensity Focused Ultrasound for Treatment of Advanced Pancreatic Adenocarcinoma	Stanford University School of Medicine	Joo Ha Hwang	Oct 13, 2020 - Oct 12, 2023	Immunotherapy
Clinical Research	Can MRg-FUS safely open the BBB in the putamen to enable drug delivery in patients with Parkinson's disease?	A pilot study for brain delivery of Cerezyme® in people with Parkinson’s disease using MR-guided focused ultrasound induced opening of the bl...	Sunnybrook Health Sciences Centre	Ying Meng	Sep 30, 2020 - Oct 31, 2020	Brain Program
Clinical Research	Is the FUS treatment of patients with pancreatic cancer effective in improving their outcomes and does this treatment result in an enhanced immunological response?	Measure immune response induced by FUS ablation for pancreatic cancer (add on to pancreatic registry)	University of Oxford	Srikanth P Reddy	Sep 23, 2020 - Sep 23, 2022	Immunotherapy
Clinical Research	Will the FUS neuromodulation of patients with perpheral neuropathy result in reduced pain and improve function?	Focused ultrasound‐induced peripheral nerve modulation	Columbia University	Elisa E Konofagou	Sep 01, 2020 - Feb 28, 2022	Brain Program
Technical	Can tractography provide more precise targets and improved treatment efficacy?	Precision Targeting of Brain for HIFU Ablative Therapy of Essential Tremor	Stanford University School of Medicine	Gary Glover	Aug 04, 2020 - Aug 03, 2021	Brain Program
Pre-Clinical	Can microbubble-enhanced focused ultrasound improve immune response from checkpoint inhibitors in a glioma model?	Focused Ultrasound Immunomodulation in a Mouse GL261 Intracranial Glioma	University of Virginia Health System	Richard J Price	Aug 01, 2020 - Jul 31, 2022	Immunotherapy
Clinical Research	Will FUS treatment of late stage cancer or mets to the pelvis be feasible, safe and initially effective?	HIFU-LATE Study: A Phase II feasibility/efficacy study of HIFU in late stage pelvic cancer	Imperial College Healthcare NHS Trust, St. Mary's Hospital	Jamie Murphy	Jul 28, 2020 - Jul 27, 2022	Research Award
Technical	Can a simplified, open-source GUI provide greater access to tractography-based targeting for the FUS community?	Development of a Clinically-Feasible Image Processing Platform for Diffusion MRI Tractography-Based Focused Ultrasound Targeting of Essential Tremor	Stanford University School of Medicine	Jennifer McNab	Jul 15, 2020 - Jan 14, 2021	Research Award
Clinical Research	Will FUS treatment of patients with Trigeminal Neuralgia be effective?	MR Guided FUS of thalamus (Central Lateral Thalamotomy) for treatment of Trigeminal Neuralgia: Feasibility and Safety Study	University of Maryland School of Medicine	Dheeraj Gandhi	Jun 08, 2020 - Jun 07, 2023	Brain Program
Pre-Clinical	Can sonodynamic therapy be used to treat cerebral cavernous malformations?	Focused Ultrasound Treatment of Cerebral Cavernous Malformations	University of Virginia Health System	Petr Tvrdik	May 05, 2020 - May 05, 2021	Brain Program
Pre-Clinical	What is the optimal timing of FUS and immunotherapy treatment?	ImmunoPET imaging-based optimization of immunotherapy delivery to brain tumors with focused ultrasound	University of Virginia Health System	Richard J Price	May 01, 2020 - May 01, 2021	Immunotherapy
Vet	Can histotripsy safely treat osteosarcoma in dogs?	Histotripsy for treatment of canine appendicular osteosarcoma	Virginia-Maryland College of Veterinary Medicine	Joanne Tuohy	Apr 20, 2020 - Apr 20, 2021	Veterinary
Vet	Can histotripsy safely treat soft tissue tumors in dogs?	Investigation of the immunostimulatory response to mechanical high intensity focused ultrasound (histotripsy) in dogs with naturally-occurring soft...	Virginia-Maryland College of Veterinary Medicine	Shawna Klahn	Apr 07, 2020 - Apr 07, 2021	Veterinary
Pre-Clinical	Which mechanical FUS mode is best at inducing a T-cell response in GBM?	Acoustic activation of the GBM-brain microenvironment for improved T-cell immunotherapy	University of Maryland School of Medicine	Graeme Woodworth	Apr 01, 2020 - Apr 01, 2022	Immunotherapy
Clinical Research	Will this neuronavigation device be able to safely and effectively open the BBB in AD patients?	Neuronavigation-guided focused ultrasound-induced blood-brain barrier opening in Alzheimer’s disease patients	Columbia University	Elisa E Konofagou	Mar 18, 2020 - Mar 17, 2021	Brain Program
Pre-Clinical	Can pulsed FUS promote stem cell therapy to treat acute kidney failure?	Priming The Injured Kidney With Pulsed Focused Ultrasound For Mesenchymal Stem Cell Therapy	Stanford University School of Medicine	Avnesh Thakor	Feb 21, 2020 - Feb 20, 2021	Research Award
Technical	Can improved acoustic simulations of trans-skull treatments be used to better predict thermal rise and thus aide in improved patient selection?	Simulation of Transcranial Focused Ultrasound Propagation for Prediction of Thermal Lesions and Patient Selection	Inserm LabTAU	Cyril Lafon	Feb 18, 2020 - Feb 17, 2021	Brain Program
Pre-Clinical	Can FUS + immunotherapies be used to treat pancreatic cancer?	FUS for pancreatic cancer	Institute of Cancer Research	Gail R ter Haar	Feb 06, 2020 - Feb 06, 2021	Immunotherapy
Pre-Clinical	Can FUS + immunotherapy treat ovarian and cervical cancer?	Activating specific cytotoxic T-cells by HIFU and systemic immunotherapy in treatment of recurrent ovarian and cervical cancer in a syngeneic animal...	Stanford University School of Medicine	Nelson Teng	Jan 28, 2020 - Feb 01, 2021	Immunotherapy
MOA	Can FUS drug delivery be used to selectively deliver anesthetic agents for targeted pain management?	The Needle-less Nerve Block: Targeted Non-Invasive Analgesia with Ultrasonic Uncaging of Local Anesthetics	Stanford University School of Medicine	Raag Dar Airan	Jan 23, 2020 - Apr 22, 2021	Research Award
Vet	Can FUS safely treat soft tissue tumors in dogs?	Investigation of the immunostimulatory response to high intensity focused ultrasound in dogs with naturally-occurring solid tumors.	Virginia-Maryland College of Veterinary Medicine	Nick Dervisis	Jan 01, 2020 - Jan 01, 2022	Veterinary
Clinical Research	Will the use of FUS to pre-operatively partially treat patients with sarcoma produce an enhanced immune response?	Adjuvant Focused Ultrasound to Promote Immunotherapy Response for Undifferentiated Pleomorphic Sarcoma	University of California, San Francisco	Matthew Bucknor	Nov 22, 2019 - May 21, 2022	Immunotherapy
Pre-Clinical	Is histotripsy a safe and effective FUS biomechanism for treating the pig pancreas, justifying the organization of a human clinical trial?	Development of Novel Porcine Models of Orthotopic Pancreatic Cancer for FUS and Histotripsy Tumor Ablation Applications	Virginia Polytechnic Institute and State University	Irving Coy Allen	Nov 12, 2019 - Nov 11, 2020	Research Award
Pre-Clinical	Can histotripsy elicit a potent anti-tumor immune response in liver cancer?	Histotripsy tumor ablation-mediated immune-stimulation	University of Michigan	Zhen Xu	Nov 06, 2019 - Nov 06, 2020	Immunotherapy
Clinical Research	Will the FUS opening of the BBB prior to chemotherapy treatment in patients with breast cancer mets to their be feasible and safe?	A Study to Evaluate the Safety and Feasibility of Blood-Brain Barrier Disruption Using MRI-Guided Focused Ultrasound in the treatment of...	Sunnybrook Health Sciences Centre	Nir Lipsman	Oct 31, 2019 - Oct 30, 2021	Brain Program
Clinical Research	Will using FUS to open the BBB in the area of the hippocampus in patients with AD improve their outcomes?	A Phase I/IIa Study: Feasibility of Blood-Brain Barrier Opening in the Hippocampus of Patients with Alzheimer’s Disease by MR-Guided Focused U...	Sunnybrook Health Sciences Centre	Nir Lipsman	Oct 30, 2019 - Oct 29, 2021	Brain Program
Technical	Can skull temperature be monitored with MR during treatment?	MRI of Skull Heating During Focused Ultrasound Neurosurgery	University of Virginia Health System	Craig Meyer	Oct 24, 2019 - Jan 24, 2022	Brain Program
Technical	Can an encapsulated MR-active agent mitigate imaging artifacts to improve image-guidance for MRI-guided FUS?	Development of Novel Acoustic Coupling Media to Improve Image Guidance and Treatment Safety in Transcranial Focused Ultrasound Procedures	University of Virginia Health System	Steven Allen	Oct 24, 2019 - Jan 24, 2021	Research Award
Technical	Can 3D MRI thermometry be used to image the entire head in three seconds?	MRI Guidance of Focused Ultrasound Neurosurgery	University of Virginia Health System	Craig Meyer	Oct 24, 2019 - Jan 24, 2022	Brain Program
Pre-Clinical	Can FUS enhance the efficacy of immunotherapeutics in a breast cancer model?	Focused ultrasound stimulation of the immune response in a breast cancer model	Inserm LabTAU	Frederic Padilla	Oct 16, 2019 - Oct 16, 2020	Immunotherapy
Pre-Clinical	Can FUS enhance the effectiveness of immunotherapies for breast and pancreatic cancer?	Focused ultrasound stimulation of the immune response in cancer models	Inserm LabTAU	Frederic Padilla	Oct 16, 2019 - Oct 16, 2020	Immunotherapy
Pre-Clinical	Can histotripsy safely and precisely ablate brain tissue?	Transcranial Histotripsy for Treatment of Brain Tumors – Initial In-vivo Pig Study	University of Michigan	Zhen Xu	Oct 01, 2019 - Sep 30, 2020	Brain Program
Technical	Is it possible to effectively treat temporal lobe epilepsy while avoiding adverse skull heating?	Investigating the Feasibility of Targeting Temporal Lobe using Transcranial MRI- Guided Focused Ultrasound	University of Maryland School of Medicine	Rao Gullapalli	Sep 13, 2019 - Sep 12, 2020	Brain Program
MOA	Can laser-generated FUS - an alternate FUS technology - be used for BBB opening?	Blood Brain Barrier (BBB) Opening of Rat by Laser-generated Focused Ultrasound Transducer	Jeju National University	Dong-Guk Paeng	Sep 10, 2019 - Mar 10, 2021	Brain Program
Pre-Clinical	Can FUS + immunotherapies control growth of pancreatic tumors?	aCD40 + ablation trial	Stanford University School of Medicine	Katherine Whittaker Ferrara	Sep 01, 2019 - Sep 01, 2020	Immunotherapy
Vet	Can FUS safely be used to treat oral tumors in dogs?	Treating veterinary cancer patients with focused ultrasound	Oklahoma State University	Ashish Ranjan	Jun 01, 2019 - Jun 01, 2020	Veterinary
Pre-Clinical	Can FUS treat tumors in the collapsed lung?	Non-Invasive Surgical Treatment of Lung Cancer	University of Virginia Health System	Jaime F Mata	May 21, 2019 - Jul 20, 2020	Research Award
Technical	Can fast multi-slice MR thermometry increase safety, accuracy and clinical workflow efficiency while maintaining compatibility with current brain treatment workstation?	Remote Fellowship in MR Imaging for FUS Applications: Incoherent CAIPI Simultaneous Multislice Thermometry	University of Virginia	William Grissom	Apr 01, 2019 - Aug 31, 2019	Brain Program
Pre-Clinical	Can FUS BBB aquaporumab delivery promote remyelination in a rat model of neuromyelitis optica?	FUS for therapy of Neuromyelitis Optica – an inflammatory demyelinating disease of the central nervous system	University of California, San Francisco	Alan S Verkman	Mar 25, 2019 - Mar 24, 2020	Research Award
Pre-Clinical	Can FUS + immunotherapeutics control pancreatic tumor growth in a mouse model?	Focused ultrasound immunomodulation for pancreatic cancer	University of Virginia Health System	Frederic Padilla	Mar 12, 2019 - Mar 12, 2020	Immunotherapy
MOA	Can microbubble concentration variations in the brain affect BBB opening with FUS?	Microbubble enhanced FUS treatments in the brain: impact of bubble distribution in a pig craniotomy model	University of Virginia Health System	Jason P Sheehan Francesco Prada	Mar 01, 2019 - Jan 22, 2020	Brain Program
Technical	Can a cross-platform (vendor agnostic) open-source skin cooling device be designed to facilitate thermal ablation close to the skin?	Convective skin-cooling device for use with existing MRgFUS systems to prevent skin burns	University of Utah	Allison Payne	Feb 28, 2019 - Nov 01, 2019	Research Award
MOA	Does microbubble concentration vary throughout the brain?	Microbubble distribution in the brain: a real-time intra-operative map to optimize FUS treatment	University of Virginia Health System	Francesco Prada	Feb 21, 2019 - Jan 22, 2020	Brain Program
Pre-Clinical	Can FUS deliver gene therapies to reverse Parkinson's Disease?	MRGFUS GENE DELIVERY FOR NEUROPROTECTION IN PARKINSON'S DISEASE	Weill Cornell Medical Center		Jan 18, 2019 - Jan 18, 2020	Brain Program
Technical	Can a standardized laboratory FUS system be designed that lowers the bar for entry to new labs and spurs the pace and quality of preclinical FUS research?	Development of a turnkey USgFUS preclinical research platform	Sonic Concepts, Inc.	Peter J Kaczkowski Kyle Morrison	Jan 04, 2019 - Jan 03, 2020	Research Award
MOA	Can extracellular vesicles be designed and fabricated to facilitate FUS drug delivery?	Drug delivery strategies using drug-loaded extracellular vesicles generated by microbubble-assisted ultrasound	University Medical Center Utrecht	Yuana Yuana	Dec 11, 2018 - Dec 10, 2019	Research Award
Technical	Can a FUS compatible 3D MR Thermometry increase safety, accuracy and clinical workflow efficiency for brain treatments?	Remote Fellowship in MR Imaging for FUS Applications: Reduced-FOV MR Thermometry	University of Virginia	William Grissom	Dec 01, 2018 - Feb 28, 2019	Brain Program
Technical	Can machine learning algorithms outperform simulation-based acoustic correction for trans-skull treatments?	Machine Learning Project (with Insightec Data) to Improve Skull Correction and Treatment Envelope		Dimitri Falco	Oct 03, 2018 - Jul 01, 2020	Brain Program
Clinical Research	Can functional-MRI imaging improve targeting and treatment outcomes in neurological FUS procedures?	Functional Neuroimaging Feedback for Focused Ultrasound Thalamotomy for Tremor Surgery	Ohio State University	Vibhor Krishna	Sep 28, 2018 - Sep 27, 2019	Research Award
Clinical Research	Does bilateral FUS ablative treatment of the anterior capsulotomy in patients with depression improve their outcomes?	A Phase 1 Trial of MR-guided Focused Ultrasound (MRgFUS) Bilateral Capsulotomy for the Treatment of Refractory Major Depressive Disorder (MDD)	Sunnybrook Health Sciences Centre	Nir Lipsman	Sep 27, 2018 - Sep 26, 2020	Brain Program
Pre-Clinical	Can FUS ablation improve varicose vein in sheep as a precursor to clinical trials?	Non-invasive varicose vein treatment by HIFU under ultrasound guidance: Phase 1C – GLP preclinical investigation		Thomas Charrel	Sep 13, 2018 - Sep 12, 2019	Research Award
Pre-Clinical	What are the optimal histotripsy parameters to ablate cholangiocarcinoma tumors?	Non-invasive Focused Ultrasound Ablation for the Treatment of Cholangiocarcinoma Liver Tumors	Virginia Polytechnic Institute and State University	Eli Vlaisavljevich	Sep 13, 2018 - Aug 30, 2020	Research Award
Technical	Can a 3D thermometry MR sequence to improve FUS treatment efficiency and safety be developed?	Remote Fellowship in MR Imaging for FUS Applications: Volumetric Thermometry	University of Virginia	William Grissom	Jul 20, 2018 - Oct 20, 2019	Brain Program
Pre-Clinical	Can FUS + RT improve treatment of brain tumors?	Focused ultrasound radiosensitization of brain tumors	University of Virginia Health System	Frederic Padilla	Jun 05, 2018 - Jun 05, 2019	Immunotherapy
Pre-Clinical	Does sonodynamic therapy cause damage to healthy brain tissue?	Safety study: sonodynamic therapy with 5-ALA in a porcine model	University of Virginia Health System		Jun 05, 2018 - Jun 05, 2019	Brain Program
Clinical Research	Does bilateral FUS ablation of the anterior capsule in patients with OCD improve their outcomes?	Phase I trial of MR-guided Focused Ultrasound (MRgFUS) bilateral capsulotomy for the treatment of refractory obsessive-compulsive disorder (OCD)	Sunnybrook Health Sciences Centre	Nir Lipsman	Jun 05, 2018 - Jun 04, 2020	Brain Program
Pre-Clinical	Can irinotecan be safely delivered across the BBB with MRgFUS?	Safety evaluation of irinotecan delivery to a rat glioma model using a clinical MRI-guided system	Brigham and Women's Hospital	Nathan J McDannold	Jun 04, 2018 - Oct 11, 2019	Research Award
Clinical Research	Does ablative FUS therapy to the ANT disrupt the pathway for partial seizures becoming generalized?	Focused ultrasound thalamotomy for the prevention of secondary generalization in focal onset epilepsy	Ohio State University	Vibhor Krishna	Jun 01, 2018 - May 31, 2018	Brain Program
Pre-Clinical	Can FUS + microbubbles mechanically destroy GBM vasculature?	Microvascular Ablation of Intracranial Gliomas with Focused Ultrasound (9L Line)	University of Virginia Health System		Apr 24, 2018 - Apr 24, 2019	Brain Program
Pre-Clinical	Can FUS + microbubbles mechanically destroy GBM vasculature?	Microvascular Ablation of Intracranial Gliomas with Focused Ultrasound (F98 Line)	University of Virginia Health System		Apr 06, 2018 - Apr 06, 2019	Brain Program
Pre-Clinical	Can FUS-mediated delivery of stem cells or mitochondria improve post-stroke outcomes?	Selective opening of the blood brain barrier using focused ultrasound combined with systemic delivery of neural progenitor cells and mitrochondria...	University of Virginia Health System	Mohammad Yashar S Kalani	Apr 04, 2018 - Sep 24, 2019	Brain Program
Pre-Clinical	Can FUS activate fluorescein to control GBM growth?	Sonodynamic therapy for treatment of C6 glioma in a rat model proof-of-concept study: Fluorescein	University of Virginia Health System	Francesco Prada	Apr 04, 2018 - Jun 09, 2019	Brain Program
Pre-Clinical	Can sonondynamic therapy treat CCMs?	Focused ultrasound for treatment of deep-seated cerebral cavernous malformations	University of Virginia Health System	Mohammad Yashar S Kalani	Mar 26, 2018 - Sep 24, 2019	Brain Program
Pre-Clinical	Can FUS delivery of quinolinic acid in the brain disconnect epileptic foci from healthy brain?	Use of low-intensity focused ultrasound for the non-invasive, focal disconnection of brain circuitry in the treatment of neurological disorders	University of Virginia Health System	Kevin Lee	Mar 18, 2018 - Jun 18, 2018	Research Award
Pre-Clinical	Can FUS consistently produce activation or repression of nerve cell activity?	Focused ultrasound mediated neuromodulation for the treatment of spinal cord injury pain	University of Maryland School of Medicine	Victor Frenkel	Mar 05, 2018 - Jun 14, 2019	Brain Program
Vet	Can FUS enhance drug delivery in dogs?	Investigation of focused ultrasound mediated enhancement of chronic non- healing wound antimicrobial therapy in client-owned dogs	Oklahoma State University	Ashish Ranjan	Feb 12, 2018 - Sep 15, 2020	Veterinary
Technical	Can trans-cranial histotripsy or BBB opening be achieved with a low cost, optically driven transducer?	Laser-generated Focused Ultrasound Transducer for Transcranial Applications	Jeju National University	Dong-Guk Paeng	Feb 08, 2018 - Apr 22, 2019	Brain Program
Technical	Can shock-wave FUS accelerate thermal ablation for large volume treatments?	Use of shock-wave exposures for accelerating thermal ablation of targeted tissue volumes	University of Washington	Vera Khokhlova	Feb 07, 2018 - Apr 06, 2019	Research Award
Pre-Clinical	Can FUS deliver drugs across the urothelium (blood-urine barrier)?	Focused Ultrasound Mediated Drug Delivery across the Urothelium	Johns Hopkins University School of Medicine	Trinity J Bivalacqua	Feb 06, 2018 - Feb 05, 2019	Research Award
Pre-Clinical	Can nanoparticles that can be triggered by HIFU at varying time points - allowing sustained drug release in multiple "cycles" as in traditional chemotherapy - be developed?	Focused Ultrasound Driven Drug Release From Theranostic Nanoparticles For The treatment Of Pancreatic Cancer	Froedtert & the Medical College of Wisconsin	Sarah White	Jan 24, 2018 - Jan 24, 2019	Research Award
Clinical Research	What proportion of treated lung cancer patients would have been candidates for one-lung flooding FUS ablation?	Accessibility and Benefit of FUS treatment for inoperable Lung Cancer Patients, a retrospective Analysis	SRH Wald-Klinikum Gera	Frank Wolfram	Dec 14, 2017 - Feb 13, 2019	Research Award
Clinical Research	Will FUS ablation in the medial thalamus in of patients with chronic craniofacial neuropathic pain improve their pain levels?	A Pilot Study of Focused Ultrasound Medial Thalamotomy for the Treatment of Neuropathic Pain from Chronic Acquired Peripheral Neuropathy	University of Virginia Health System	William Jeff Elias	Dec 01, 2017
Pre-Clinical	Can FUS safely enhance the delivery of anti-amyloid antibodies in an Alzheimer's model?	Effects of FUS on CNS Uptake and Efficacy of an Anti-Amyloid Antibody in Aged Alzheimer’s Transgenic Mice - Cohort 2	Brigham and Women's Hospital	Cynthia Lemere	Nov 30, 2017 - Mar 30, 2018	Research Award
Technical	Can acoustic reflections be used for trans-skull focal spot verification and visualization?	Acoustic Backscatter-based 3D Mapping of Cavitation and Skull Surface in Histotripsy Transcranial Applications	University of Michigan	Jonathan Sukovich	Oct 31, 2017 - Dec 31, 2018	Research Award
Clinical Research	Will treatment of patients with chronic back pain with the FUSmobile device result in improved outcomes?	Safety and initial feasibility of using the Neurolyser XR device for the treatment of facet related low back pain	McGill University	Jordi Perez	Sep 26, 2017 - Mar 25, 2019	Research Award
Clinical Research	Will the use of FUS coupled with immunotherapy in patients with metatstatic breast cancer result in an enhanced immune response and improve their outcomes?	Focused Ultrasound Therapy to Augment Antigen Presentation and Immune-Specificity of Checkpoint Inhibitor Therapy with Pembrolizumab for Metastatic...	University of Virginia Health System	Patrick M Dillon	Sep 25, 2017
Pre-Clinical	Can FUS deliver adeno-associated virus (AAV) through the BBB to facilitate gene therapy in the brain?	MRgFUS Blood-Brain Barrier Drug Delivery with AAV2 Gene Therapy Microbubble Drug Conjugates	Sunnybrook Health Sciences Centre	James Keenan	Sep 01, 2017 - Aug 31, 2018	Research Award
Pre-Clinical	Is FUS safe and effective at treating sacroiliac pain in pigs, and can a clinical study then be organized?	Safety and Effectiveness of Sacroiliac Joint Palliation in Swine using MRgFUS	University of California, San Francisco	Roland Krug	Jul 01, 2017 - Jun 30, 2018	Research Award
Pre-Clinical	Can microbubble-enhanced focused ultrasound improve immune response in a glioma model?	Focused Ultrasound Immunomodulation in a Mouse GL261 Intracranial Glioma	Brigham and Women's Hospital	Nathan J McDannold	May 17, 2017 - Jun 19, 2019	Immunotherapy
Pre-Clinical	Can FUS enhance the effectiveness of immunotherapies for metastatic melanoma?	Focused Ultrasound to Enhance Immunotherapy for Metastatic Brain Melanoma	Columbia University	Simon Cheng	May 05, 2017 - May 05, 2019	Immunotherapy
Pre-Clinical	Can hyperthermia improve immune response in a glioma model?	Focused Ultrasound Immunomodulation in a Mouse GL261 Intracranial Glioma	Georgia Institute of Technology	Costas Arvanitis	May 01, 2017 - Apr 02, 2018	Immunotherapy
MOA	Can FUS plus heat shock-responsive gene "switches" be used to drive targeted bone regrowth?	Patterning of bone regeneration via ultrasound activation of heat shock- responsive gene switches	University of Michigan	Mario Fabiilli	Mar 01, 2017 - Feb 28, 2018	Research Award
Clinical Research	Will unilateral treatment of the STN in patients with movement disorders from Parkinson's disease improve there outcomes?	A Prospective, Randomized, Sham Controlled Study to Evaluate the Safety and Efficacy of ExAblate Subthalamotomy for the Treatment of Parkinson’s D...	Centro Integral de Neurociencias HM Cinac	Jose Obeso	Mar 01, 2017 - Sep 01, 2020	Brain Program
Clinical Research	Will FUS ablation in children with benign central tumors improve their outcomes?	A Feasibility Safety Study Using the ExAblate 4000 system in Management of Benign Centrally-Located Intracranial Tumors Which Require Clinical...	Nicklaus Children's Hospital	John Ragheb	Feb 27, 2017 - Feb 26, 2019	Brain Program
Technical	Can MRI imaging be used in conjunction with (standard of care) CT to improve prediction of skull properties and improve trans-skull focusing?	Acoustic Parameters of Bone as a function of HU and MRI	Stanford University School of Medicine	Kim Butts-Pauly	Feb 20, 2017 - Feb 21, 2018	Brain Program
Clinical Research	Will the use of FUS to treat the bilateral thalamus improve the outcomes in patients with neuropathic pain?	Phase 1 Clinical Trial of MR Guided Focused Ultrasound (FUS) Thalamotomy of Central Lateral Thalamic Nucleus for the Treatment of Neuropathic Pain	University of Maryland School of Medicine	Dheeraj Gandhi	Jan 19, 2017 - Jul 19, 2019	Brain Program
Clinical Research	Can FUS safely, temporarily and repeatedly open the BBB in patients with AD?	A Study to Evaluate the Safety and Feasibility of Blood-Brain Barrier (BBB) Opening Using Transcranial MR-Guided Focused Ultrasound with Intravenous...	Sunnybrook Health Sciences Centre	Nir Lipsman	Jan 12, 2017 - Jan 11, 2019	Brain Program
Pre-Clinical	Can thermal ablation improve immune response to a glioma model?	Focused Ultrasound Immunomodulation in a Mouse GL261 Intracranial Glioma	Sunnybrook Health Sciences Centre	Kullervo Hynynen	Nov 29, 2016 - Jun 17, 2019	Brain Program
Technical	Can MR be used in real time to monitor treatment induced tissue changes?	Real-time Treatment Monitoring by Diffusion MRI	University of Virginia Health System	Craig Meyer	Nov 29, 2016 - Nov 28, 2017	Brain Program
Pre-Clinical	What are the optimal FUS exposure settings for inducing an immune response in a mouse model of breast cancer?	Ultrasound-induced immune response on breast cancer	University of Virginia Health System	Cyril Lafon	Nov 28, 2016 - Apr 09, 2020	Immunotherapy
Pre-Clinical	Can histotripsy improve immune response in glioma model?	Focused Ultrasound Immunomodulation in a Mouse GL261 Intracranial Glioma	University of Michigan	Zhen Xu	Nov 07, 2016 - Jul 05, 2017	Brain Program
MOA		Noninvasive targeted neuromodulation and functional imaging in behaving macaques	Vanderbilt University	Charles Caskey	Sep 23, 2016 - Jun 30, 2020	Research Award
Pre-Clinical	What is the immune response induced by FUS + CTLA4 in a pancreatic cancer model?	Defining Basic Properties of Physical Immunotherapy using HIFU and Immune Checkpoint Inhibition	Institute of Cancer Research	Gail R ter Haar	Sep 07, 2016 - Jun 07, 2019	Immunotherapy
MOA		FUS-mediated Neuromodulation from Unanesthetized Freely-moving Animals	Brigham and Women's Hospital	Wonhye Lee	Sep 01, 2016 - Aug 31, 2020	Research Award
Pre-Clinical	Can FUS-mediated delivery of antibodies reduce buildup of alpha synuclein in the brain?	Antibody Delivery Through the BBB Opening in an Alpha-Synuclein Model	Columbia University	Elisa E Konofagou	Aug 15, 2016 - Feb 04, 2019	Brain Program

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