Foundation Funded Research Projects

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Showing 100 out of 223 research projects
Category Research Question Project Name (Click on the project name for more info) Primary Research Site Principal Investigator Funding Dates Program
Pre-Clinical Does boiling histotripsy, cavitational histotripsy, or thermal ablation produce a stronger immune response?
  • Multimodal analysis of immune response post-FUS in two tumor models
  • University of Michigan
      May 23, 2022 - Jun 23, 2022 Immunotherapy
      Vet Can burst wave lithotripsy be scaled to safely and effectively fragment urinary tract stones in pet feline patient volunteers with naturally occurring urolithiasis.
    • Evaluation of a veterinary focused ultrasound device to noninvasively fragment feline urinary tract stones
    • University of Washington Apr 11, 2022 - Apr 11, 2023 Veterinary
      Pre-Clinical Is ultrasound guidance sufficient for FUS treatment of the sacroiliac joint, and can a clinical trial be launched for such a device?
    • Preclinical Investigation of Ultrasound-Guided Focused Ultrasound Therapy for Sacroiliac Joint Low Back Pain
    • Memorial Sloan-Kettering Cancer Center Apr 04, 2022 - Oct 04, 2022 Research Award
      Pre-Clinical Can FUS BBB benefit PD patients?
    • FUS BBB opening to halt nigrostriatal degeneration
    • Centro Integral de Neurociencias HM Cinac
        Mar 29, 2022 - Mar 29, 2024 Brain Program
        Pre-Clinical Do monodisperse (4-5um) MBs enhance intertumoral drug penetration and distribution of chemotherapeutics in neuroblastoma mouse tumor model (compared to Definity and SonoVue)?
      • The use of monodisperse size-isolated microbubbles for improving the safety and efficacy of chemotherapeutics in neuroblastoma treatment
      • Mar 11, 2022 - Mar 10, 2023 Research Award
        Pre-Clinical Is MRI-g-FUS mediated delivery of AAV9.SIRT3-myc as effective as a disease-modifying strategy and safer with fewer side effected compared to a more widely used, yet more invasive, less safe gene delivery approach?
      • FUS-meditated delivery of the neurorestorative gene therapy, rAAV9.SIRT3-myc as a disease-modifying strategy in Parkinson’s disease
      • University of Toronto Feb 07, 2022 - Dec 31, 1969 Brain Program
        Pre-Clinical Can FUS open the blood-CSF barrier to enable drug delivery to the leptomeninges and reduce tumor burden / improve survival?
      • MRg-FUS-mediated leptomeninges opening to facilitate the targeted drug delivery in leptomeningeal brain metastases
      • Seoul National University Hospital Jan 17, 2022 - Jan 17, 2023 Brain Program
        Pre-Clinical Does modified-RNA therapy to CNS reduce intracellular cholesterol accumulation?
      • Enhancing delivery of molecular therapies to the CNS for genetic neurological disorders
      • Brigham and Women's Hospital Jan 13, 2022 - Jan 13, 2023 Brain Program
        Technical Can simulations of transcranial MRgFUS procedures be improved based on thermometry imagery from patient treatments?
      • Optimizing relationships between skull density and acoustic properties using magnetic resonance temperature imaging obtained during clinical focused...
      • Brigham and Women's Hospital Jan 13, 2022 - Jan 13, 2023 Brain Program
        Vet Can FUS-mediated gene therapy induce an anti-tumor response in canine liver cancer?
      • Ultrasound (US)-microbubble (MB)-delivered microRNA-mediated immunomodulation for liver malignancy therapy in veterinary clinical practice
      • Stanford University School of Medicine Nov 15, 2021 - Nov 14, 2023 Veterinary
        Pre-Clinical Can FUS + immunotherapy effectively treat a mouse model of pediatric rhabdomyosarcoma?
      • Treating Pediatric Rhabdomyosarcoma Using HIFU Histotripsy or Ablation in Combination with Immunotherapy
      • Children's National Hospital Oct 22, 2021 - Oct 22, 2022 Immunotherapy
        Clinical Research Can Brigham implement a published method for subthalamic segmentation to improve targeting in ET patients?
      • Symptom mapping for FUS thalamotomy assessment and planning
      • Brigham and Women's Hospital Oct 07, 2021 - Oct 06, 2022 Brain Program
        Clinical Research Will the FUS opening of the BBB and chemotherapy infusion prior to biopsy or resection in patients with recurrent brain tumors be feasible, safe and show that enhanced treatment of the tumor?
      • Clinical investigation of Farydak (panobinostat) for the treatment of Pediatric Diffuse Midline Glioma (DMG)
      • Columbia University Oct 05, 2021 - Apr 04, 2024 Brain Program
        Vet Can FUS be used to treat prostate cancer in canines?
      • FUS for canine prostate cancer
      • Sep 10, 2021 - Sep 10, 2022 Veterinary
        Clinical Research Will ablation of the pallidothalamic tract treat cervical dystonia?
      • A pilot trial of safety and effectiveness of Magnetic Resonance-guided Focused Ultrasound (MRgFUS) Ablation of the pallidothalamic tract for the...
      • Tokyo Women's Medical University Hospital Aug 10, 2021 - Aug 09, 2023 Brain Program
        Pre-Clinical Can specially engineered nanoparticles improve gene-based immunotherapy for brain tumors?
      • Ultrasound-guided gene delivery to brain tumors
      • University of Virginia Health System Aug 01, 2021 - Aug 01, 2022 Immunotherapy
        Technical
      • Next Gen. Scholar Project: Open source MR thermometry pipeline for the Siemens MRI platform
      • Hospital for Sick Children Jul 18, 2021 - Dec 31, 2021 Research Award
        Vet Is histotripsy or HIFU better for treating feline sarcomas?
      • FUS for feline sarcomas
      • Virginia-Maryland College of Veterinary Medicine Jul 01, 2021 - Jul 01, 2022 Veterinary
        Pre-Clinical Can FUS neuromodulation of the liver increase insulin sensitivity in a hyperglycemia and insulin resistance in a porcine model?
      • Noninvasive, imaged-guided, focused ultrasound neuromodulation of the liver for control of post-operative hyperglycemia in a swine model
      • Northwell Health, Feinstein Institutes for Medical Research Jun 21, 2021 - Jun 20, 2022 Research Award
        Technical Can transcranial MRgFUS create a clinically relevant thermal increase in the human cingulate cortex without appreciable heating of important surrounding structures?
      • Transcranial magnetic resonance–guided focused ultrasound surgery for cingulotomy: a cadaveric and laboratory feasibility study
      • Ohio State University Jun 08, 2021 - Sep 09, 2021 Brain Program
        Pre-Clinical Can neural network analysis of histological slides of histotripsy lesions quantify a dose metric?
      • Next Gen. Scholar Project: Quantitative Assessments of Biological Tissue Susceptibility to Mechanical Bioeffects Induced by High Intensity Focused...
      • University of Washington May 30, 2021 - Oct 31, 2021 Research Award
        Clinical Research Will the use of FUS improve the absorption of FOLFIRINOX?
      • Evaluation of therapeutic efficacy and safety of concurrent FOLFIRINOX plus HIFU (ALPIUS 900) for locally advanced/borderline resectable PancCA: A...
      • Seoul National University Hospital May 13, 2021 - May 12, 2023 Liver/Pancreas Program
        Pre-Clinical Is transcranial histotripsy safe?
      • Transcranial Histotripsy Application to Cadaveric Brain
      • University of Michigan Apr 30, 2021 - Mar 21, 2022 Brain Program
        MOA Does variation in microbubble concentration affect BBB opening with FUS?
      • Microbubble enhanced FUS treatments in the brain: impact of bubble distribution in a pig craniotomy model
      • Fondazione IRCCS Istituto Neurologico Carlo Besta Apr 20, 2021 - Apr 20, 2022 Brain Program
        Technical
      • Development of a transcranial sonication efficiency estimation toolkit
      • Jeju National University Mar 01, 2021 - Feb 28, 2023 Brain Program
        Technical Can ultrasound image the focal area of a FUS transducer in vivo?
      • Ultrasonic visualization of the focal area in High Intensity Focused Ultrasound field
      • Stanford University School of Medicine Feb 26, 2021 - Feb 25, 2022 Research Award
        Clinical Research Does pulsed FUS increase circulating brain tumor biomarkers to enhance efficacy of liquid biopsy
      • Ultrasound enabled detection of circulating tumor biomarkers for glioblastoma
      • Northwestern University Feb 26, 2021 - Feb 25, 2022 Brain Program
        Clinical Research Will opening the BBB with the NaviFUS device in patients with GBM combined with Avastin therapy improve their outcomes?
      • An open label, prospective, pilot study to evaluate the efficacy and safety of best physician’s choice of standard of care combined with or without N...
      • Chang Gung Memorial Hospital, Taoyuan Dec 21, 2020 - Dec 20, 2021 Brain Program
        Vet Can histotripsy safely treat brain tumors in dogs?
      • Ultrasound-guided histotripsy ablation of spontaneous brain tumors in canines through a cranial window
      • Virginia Polytechnic Institute and State University Dec 01, 2020 - Dec 01, 2021 Veterinary
        Pre-Clinical Can FUS plasmid delivery enhance gene expression?
      • Enhancing Neurogenesis by Focused Ultrasound-mediated Plasmid Delivery
      • University of Virginia Health System Nov 06, 2020 - Nov 05, 2021 Research Award
        Technical What is the appropriate metric by which to report dose for histotripsy sonications?
      • Real-time Transcranial Histotripsy Dose Monitoring via Acoustic Cavitation Emission (ACE) Feedback Methods
      • University of Michigan Oct 13, 2020 - Oct 12, 2021 Brain Program
        Clinical Research Will FUS treatment of pancreatic cancer impact the anti-tumor immune response and improve survival?
      • A Phase I Study of Magnetic Resonance Guided High Intensity Focused Ultrasound for Treatment of Advanced Pancreatic Adenocarcinoma
      • Stanford University School of Medicine Oct 13, 2020 - Oct 12, 2023 Immunotherapy
        Clinical Research Can MRg-FUS safely open the BBB in the putamen to enable drug delivery in patients with Parkinson's disease?
      • A pilot study for brain delivery of Cerezyme® in people with Parkinson’s disease using MR-guided focused ultrasound induced opening of the bl...
      • Sunnybrook Health Sciences Centre Sep 30, 2020 - Oct 31, 2020 Brain Program
        Pre-Clinical Is FUS safe and effective at treating sacroiliac pain in pigs, and can a clinical study then be organized?
      • Safety and Effectiveness of Sacroiliac Joint Palliation in Swine using MRgFUS
      • University of California, San Francisco Sep 30, 2020 - Sep 29, 2023 Research Award
        Clinical Research Is the FUS treatment of patients with pancreatic cancer effective in improving their outcomes and does this treatment result in an enhanced immunological response?
      • Measure immune response induced by FUS ablation for pancreatic cancer (add on to pancreatic registry)
      • University of Oxford Sep 23, 2020 - Sep 23, 2022 Immunotherapy
        Clinical Research Will the FUS neuromodulation of patients with perpheral neuropathy result in reduced pain and improve function?
      • Focused ultrasound‐induced peripheral nerve modulation
      • Columbia University Sep 01, 2020 - Feb 28, 2022 Brain Program
        Technical Can 3D MRI thermometry be used to image the entire head in three seconds?
      • MRI Guidance of Focused Ultrasound Neurosurgery
      • University of Virginia Health System Sep 01, 2020 - Aug 31, 2024 Brain Program
        Technical Can tractography provide more precise targets and improved treatment efficacy?
      • Precision Targeting of Brain for HIFU Ablative Therapy of Essential Tremor
      • Stanford University School of Medicine Aug 04, 2020 - Aug 03, 2021 Brain Program
        Clinical Research Will FUS treatment of late stage cancer or mets to the pelvis be feasible, safe and initially effective?
      • HIFU-LATE Study: A Phase II feasibility/efficacy study of HIFU in late stage pelvic cancer
      • Imperial College Healthcare NHS Trust, St. Mary's Hospital Jul 28, 2020 - Jul 27, 2022 Research Award
        Technical Can a simplified, open-source GUI provide greater access to tractography-based targeting for the FUS community?
      • Development of a Clinically-Feasible Image Processing Platform for Diffusion MRI Tractography-Based Focused Ultrasound Targeting of Essential Tremor
      • Stanford University School of Medicine Jul 15, 2020 - Jan 14, 2021 Research Award
        Clinical Research Will FUS treatment of patients with Trigeminal Neuralgia be effective?
      • MR Guided FUS of thalamus (Central Lateral Thalamotomy) for treatment of Trigeminal Neuralgia: Feasibility and Safety Study
      • University of Maryland School of Medicine Jun 08, 2020 - Jun 07, 2023 Brain Program
        Pre-Clinical Can sonodynamic therapy be used to treat cerebral cavernous malformations?
      • Focused Ultrasound Treatment of Cerebral Cavernous Malformations
      • University of Virginia Health System May 05, 2020 - May 05, 2021 Brain Program
        Pre-Clinical What is the optimal timing of FUS and immunotherapy treatment?
      • ImmunoPET imaging-based optimization of immunotherapy delivery to brain tumors with focused ultrasound
      • University of Virginia Health System May 01, 2020 - May 01, 2021 Immunotherapy
        Vet Can histotripsy safely treat osteosarcoma in dogs?
      • Histotripsy for treatment of canine appendicular osteosarcoma
      • Virginia-Maryland College of Veterinary Medicine Apr 20, 2020 - Apr 20, 2021 Veterinary
        Vet Can histotripsy safely treat soft tissue tumors in dogs?
      • Investigation of the immunostimulatory response to mechanical high intensity focused ultrasound (histotripsy) in dogs with naturally-occurring soft...
      • Virginia-Maryland College of Veterinary Medicine Apr 07, 2020 - Apr 07, 2021 Veterinary
        Pre-Clinical Which mechanical FUS mode is best at inducing a T-cell response in GBM?
      • Acoustic activation of the GBM-brain microenvironment for improved T-cell immunotherapy
      • University of Maryland School of Medicine Apr 01, 2020 - Apr 01, 2022 Immunotherapy
        Clinical Research Will this neuronavigation device be able to safely and effectively open the BBB in AD patients?
      • Neuronavigation-guided focused ultrasound-induced blood-brain barrier opening in Alzheimer’s disease patients
      • Columbia University Mar 18, 2020 - Mar 17, 2021 Brain Program
        Pre-Clinical Can pulsed FUS promote stem cell therapy to treat acute kidney failure?
      • Priming The Injured Kidney With Pulsed Focused Ultrasound For Mesenchymal Stem Cell Therapy
      • Stanford University School of Medicine Feb 21, 2020 - Feb 20, 2021 Research Award
        Technical Can improved acoustic simulations of trans-skull treatments be used to better predict thermal rise and thus aide in improved patient selection?
      • Simulation of Transcranial Focused Ultrasound Propagation for Prediction of Thermal Lesions and Patient Selection
      • Inserm LabTAU Feb 18, 2020 - Feb 17, 2021 Brain Program
        Pre-Clinical Can FUS + immunotherapies be used to treat pancreatic cancer?
      • FUS for pancreatic cancer
      • Institute of Cancer Research Feb 06, 2020 - Feb 06, 2021 Immunotherapy
        Pre-Clinical Can FUS + immunotherapy treat ovarian and cervical cancer?
      • Activating specific cytotoxic T-cells by HIFU and systemic immunotherapy in treatment of recurrent ovarian and cervical cancer in a syngeneic animal...
      • Stanford University School of Medicine Jan 28, 2020 - Feb 01, 2021 Immunotherapy
        MOA Can FUS drug delivery be used to selectively deliver anesthetic agents for targeted pain management?
      • The Needle-less Nerve Block: Targeted Non-Invasive Analgesia with Ultrasonic Uncaging of Local Anesthetics
      • Stanford University School of Medicine Jan 23, 2020 - Apr 22, 2021 Research Award
        Vet Can FUS safely treat soft tissue tumors in dogs?
      • Investigation of the immunostimulatory response to high intensity focused ultrasound in dogs with naturally-occurring solid tumors.
      • Virginia-Maryland College of Veterinary Medicine Jan 01, 2020 - Jan 01, 2022 Veterinary
        Clinical Research Will the use of FUS to pre-operatively partially treat patients with sarcoma produce an enhanced immune response?
      • Adjuvant Focused Ultrasound to Promote Immunotherapy Response for Undifferentiated Pleomorphic Sarcoma
      • University of California, San Francisco Nov 22, 2019 - May 21, 2022 Immunotherapy
        Pre-Clinical Is histotripsy a safe and effective FUS biomechanism for treating the pig pancreas, justifying the organization of a human clinical trial?
      • Development of Novel Porcine Models of Orthotopic Pancreatic Cancer for FUS and Histotripsy Tumor Ablation Applications
      • Virginia Polytechnic Institute and State University Nov 12, 2019 - Nov 11, 2020 Research Award
        Pre-Clinical Can histotripsy elicit a potent anti-tumor immune response in liver cancer?
      • Histotripsy tumor ablation-mediated immune-stimulation
      • University of Michigan Nov 06, 2019 - Nov 06, 2020 Immunotherapy
        Clinical Research Will the FUS opening of the BBB prior to chemotherapy treatment in patients with breast cancer mets to their be feasible and safe?
      • A Study to Evaluate the Safety and Feasibility of Blood-Brain Barrier Disruption Using MRI-Guided Focused Ultrasound in the treatment of...
      • Sunnybrook Health Sciences Centre Oct 31, 2019 - Oct 30, 2021 Brain Program
        Clinical Research Will using FUS to open the BBB in the area of the hippocampus in patients with AD improve their outcomes?
      • A Phase I/IIa Study: Feasibility of Blood-Brain Barrier Opening in the Hippocampus of Patients with Alzheimer’s Disease by MR-Guided Focused U...
      • Sunnybrook Health Sciences Centre Oct 30, 2019 - Oct 29, 2021 Brain Program
        Technical Can an encapsulated MR-active agent mitigate imaging artifacts to improve image-guidance for MRI-guided FUS?
      • Development of Novel Acoustic Coupling Media to Improve Image Guidance and Treatment Safety in Transcranial Focused Ultrasound Procedures
      • University of Virginia Health System Oct 24, 2019 - Jan 24, 2021 Research Award
        Technical Can skull temperature be monitored with MR  during treatment?
      • MRI of Skull Heating During Focused Ultrasound Neurosurgery
      • University of Virginia Health System Oct 24, 2019 - Jan 24, 2022 Brain Program
        Pre-Clinical Can FUS enhance the efficacy of immunotherapeutics in a breast cancer model?
      • Focused ultrasound stimulation of the immune response in a breast cancer model
      • Inserm LabTAU Oct 16, 2019 - Oct 16, 2020 Immunotherapy
        Pre-Clinical Can FUS enhance the effectiveness of immunotherapies for breast and pancreatic cancer?
      • Focused ultrasound stimulation of the immune response in cancer models
      • Inserm LabTAU Oct 16, 2019 - Oct 01, 2022 Immunotherapy
        Pre-Clinical Can histotripsy safely and precisely ablate brain tissue?
      • Transcranial Histotripsy for Treatment of Brain Tumors – Initial In-vivo Pig Study
      • University of Michigan Oct 01, 2019 - Sep 30, 2020 Brain Program
        Technical Is it possible to effectively treat temporal lobe epilepsy while avoiding adverse skull heating?
      • Investigating the Feasibility of Targeting Temporal Lobe using Transcranial MRI- Guided Focused Ultrasound
      • University of Maryland School of Medicine Sep 13, 2019 - Jul 31, 2021 Brain Program
        MOA Can laser-generated FUS - an alternate FUS technology - be used for BBB opening?
      • Blood Brain Barrier (BBB) Opening of Rat by Laser-generated Focused Ultrasound Transducer
      • Jeju National University Sep 10, 2019 - Mar 10, 2021 Brain Program
        Pre-Clinical Can FUS + immunotherapies control growth of pancreatic tumors?
      • aCD40 + ablation trial
      • Stanford University School of Medicine Sep 01, 2019 - Dec 31, 2021 Immunotherapy
        Vet Can FUS safely be used to treat tumors in dogs?
      • Treating veterinary cancer patients with focused ultrasound
      • Oklahoma State University Jun 01, 2019 - Jun 01, 2020 Veterinary
        Pre-Clinical Can FUS treat tumors in the collapsed lung?
      • Non-Invasive Surgical Treatment of Lung Cancer
      • University of Virginia Health System May 21, 2019 - Nov 04, 2022 Research Award
        Technical Can fast multi-slice MR thermometry increase safety, accuracy and clinical workflow efficiency while maintaining compatibility with current brain treatment workstation?
      • Remote Fellowship in MR Imaging for FUS Applications: Incoherent CAIPI Simultaneous Multislice Thermometry
      • University of Virginia Apr 01, 2019 - Aug 31, 2019 Brain Program
        Pre-Clinical Can FUS BBB aquaporumab delivery promote remyelination in a rat model of neuromyelitis optica?
      • FUS for therapy of Neuromyelitis Optica – an inflammatory demyelinating disease of the central nervous system
      • University of California, San Francisco Mar 25, 2019 - Mar 24, 2020 Research Award
        Pre-Clinical Can FUS + immunotherapeutics control pancreatic tumor growth in a mouse model?
      • Focused ultrasound immunomodulation for pancreatic cancer
      • University of Virginia Health System Mar 12, 2019 - Mar 12, 2020 Immunotherapy
        MOA Can microbubble concentration variations in the brain affect BBB opening with FUS?
      • Microbubble enhanced FUS treatments in the brain: impact of bubble distribution in a pig craniotomy model
      • University of Virginia Health System Mar 01, 2019 - Jan 22, 2020 Brain Program
        Technical Can a cross-platform (vendor agnostic) open-source skin cooling device be designed to facilitate thermal ablation close to the skin?
      • Convective skin-cooling device for use with existing MRgFUS systems to prevent skin burns
      • University of Utah Feb 28, 2019 - Nov 01, 2019 Research Award
        MOA Does microbubble concentration vary throughout the brain?
      • Microbubble distribution in the brain: a real-time intra-operative map to optimize FUS treatment
      • University of Virginia Health System Feb 21, 2019 - Jan 22, 2020 Brain Program
        Technical Can a standardized laboratory FUS system be designed that lowers the bar for entry to new labs and spurs the pace and quality of preclinical FUS research?
      • Development of a turnkey USgFUS preclinical research platform
      • Sonic Concepts, Inc. Jan 04, 2019 - Jan 03, 2020 Research Award
        MOA Can extracellular vesicles be designed and fabricated to facilitate FUS drug delivery?
      • Drug delivery strategies using drug-loaded extracellular vesicles generated by microbubble-assisted ultrasound
      • University Medical Center Utrecht Dec 11, 2018 - Dec 10, 2019 Research Award
        Technical Can a FUS compatible 3D MR Thermometry increase safety, accuracy and clinical workflow efficiency for brain treatments?
      • Remote Fellowship in MR Imaging for FUS Applications: Reduced-FOV MR Thermometry
      • University of Virginia Dec 01, 2018 - Feb 28, 2019 Brain Program
        Technical Can machine learning algorithms outperform simulation-based acoustic correction for trans-skull treatments?
      • Machine Learning Project (with Insightec Data) to Improve Skull Correction and Treatment Envelope
      • Oct 03, 2018 - Jul 01, 2020 Brain Program
        Clinical Research Can functional-MRI imaging improve targeting and treatment outcomes in neurological FUS procedures?
      • Functional Neuroimaging Feedback for Focused Ultrasound Thalamotomy for Tremor Surgery
      • Ohio State University Sep 28, 2018 - Sep 27, 2019 Research Award
        Clinical Research Does bilateral FUS ablative treatment of the anterior capsulotomy in patients with depression improve their outcomes?
      • A Phase 1 Trial of MR-guided Focused Ultrasound (MRgFUS) Bilateral Capsulotomy for the Treatment of Refractory Major Depressive Disorder (MDD)
      • Sunnybrook Health Sciences Centre Sep 27, 2018 - Sep 26, 2020 Brain Program
        Pre-Clinical Can FUS ablation improve varicose vein in sheep as a precursor to clinical trials?
      • Non-invasive varicose vein treatment by HIFU under ultrasound guidance: Phase 1C – GLP preclinical investigation
      • Sep 13, 2018 - Oct 31, 2021 Research Award
        Pre-Clinical What are the optimal histotripsy parameters to ablate cholangiocarcinoma tumors?
      • Non-invasive Focused Ultrasound Ablation for the Treatment of Cholangiocarcinoma Liver Tumors
      • Virginia Polytechnic Institute and State University Sep 13, 2018 - Aug 30, 2020 Research Award
        Technical Can a 3D thermometry MR sequence to improve FUS treatment efficiency and safety be developed?
      • Remote Fellowship in MR Imaging for FUS Applications: Volumetric Thermometry
      • University of Virginia Jul 20, 2018 - Oct 20, 2019 Brain Program
        Pre-Clinical Can FUS + RT improve treatment of brain tumors?
      • Focused ultrasound radiosensitization of brain tumors
      • University of Virginia Health System Jun 05, 2018 - Jun 05, 2019 Brain Program
        Clinical Research Does bilateral FUS ablation of the anterior capsule in patients with OCD improve their outcomes?
      • Phase I trial of MR-guided Focused Ultrasound (MRgFUS) bilateral capsulotomy for the treatment of refractory obsessive-compulsive disorder (OCD)
      • Sunnybrook Health Sciences Centre Jun 05, 2018 - Jun 04, 2020 Brain Program
        Pre-Clinical Does sonodynamic therapy cause damage to healthy brain tissue?
      • Safety study: sonodynamic therapy with 5-ALA in a porcine model
      • University of Virginia Health System Jun 05, 2018 - Jun 05, 2019 Brain Program
        Pre-Clinical Can irinotecan be safely delivered across the BBB with MRgFUS?
      • Safety evaluation of irinotecan delivery to a rat glioma model using a clinical MRI-guided system
      • Brigham and Women's Hospital Jun 04, 2018 - Oct 11, 2019 Research Award
        Clinical Research Does ablative FUS therapy to the ANT disrupt the pathway for partial seizures becoming generalized?
      • Focused ultrasound thalamotomy for the prevention of secondary generalization in focal onset epilepsy
      • Ohio State University Jun 01, 2018 - May 31, 2018 Brain Program
        Pre-Clinical Can FUS delivery of quinolinic acid in the brain disconnect epileptic foci from healthy brain?
      • Use of low-intensity focused ultrasound for the non-invasive, focal disconnection of brain circuitry in the treatment of neurological disorders
      • University of Virginia Health System May 15, 2018 - May 15, 2023 Research Award
        Pre-Clinical Can FUS deliver gene therapies to reverse Parkinson's Disease?
      • MRGFUS GENE DELIVERY FOR NEUROPROTECTION IN PARKINSON'S DISEASE
      • Weill Cornell Medical Center
          May 01, 2018 - Apr 30, 2019 Brain Program
          Pre-Clinical Can FUS + microbubbles mechanically destroy GBM vasculature?
        • Microvascular Ablation of Intracranial Gliomas with Focused Ultrasound (9L Line)
        • University of Virginia Health System
            Apr 24, 2018 - Apr 24, 2019 Brain Program
            Pre-Clinical Can FUS + microbubbles mechanically destroy GBM vasculature?
          • Microvascular Ablation of Intracranial Gliomas with Focused Ultrasound (F98 Line)
          • University of Virginia Health System
              Apr 06, 2018 - Apr 06, 2019 Brain Program
              Pre-Clinical Can FUS-mediated delivery of stem cells or mitochondria improve post-stroke outcomes?
            • Selective opening of the blood brain barrier using focused ultrasound combined with systemic delivery of neural progenitor cells and mitrochondria...
            • University of Virginia Health System Apr 04, 2018 - Sep 24, 2019 Brain Program
              Pre-Clinical Can FUS activate fluorescein to control GBM growth?
            • Sonodynamic therapy for treatment of C6 glioma in a rat model proof-of-concept study: Fluorescein
            • University of Virginia Health System Apr 04, 2018 - Jun 09, 2019 Brain Program
              Pre-Clinical Can sonondynamic therapy treat CCMs?
            • Focused ultrasound for treatment of deep-seated cerebral cavernous malformations
            • University of Virginia Health System Mar 26, 2018 - Sep 24, 2019 Brain Program
              Pre-Clinical Can FUS consistently produce activation or repression of nerve cell activity?
            • Focused ultrasound mediated neuromodulation for the treatment of spinal cord injury pain
            • University of Maryland School of Medicine Mar 05, 2018 - Jun 14, 2019 Brain Program
              Vet Can FUS enhance drug delivery in dogs?
            • Investigation of focused ultrasound mediated enhancement of drug delivery in client-owned dogs
            • Oklahoma State University Feb 12, 2018 - Sep 15, 2020 Veterinary
              Technical Can trans-cranial histotripsy or BBB opening be achieved with a low cost, optically driven transducer?
            • Laser-generated Focused Ultrasound Transducer for Transcranial Applications
            • Jeju National University Feb 08, 2018 - Apr 22, 2019 Brain Program
              Technical Can shock-wave FUS accelerate thermal ablation for large volume treatments?
            • Use of shock-wave exposures for accelerating thermal ablation of targeted tissue volumes
            • University of Washington Feb 07, 2018 - Apr 06, 2019 Research Award
              Pre-Clinical Can FUS deliver drugs across the urothelium (blood-urine barrier)?
            • Focused Ultrasound Mediated Drug Delivery across the Urothelium
            • Johns Hopkins University School of Medicine Feb 06, 2018 - Feb 05, 2019 Research Award
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