Foundation Funded Research Projects

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Showing 100 out of 180 research projects
Category Research Question Project Name (Click on the project name for more info) Primary Research Site Principal Investigator Funding Dates Program
Clinical Trial Will the FUS neuromodulation of patients with perpheral neuropathy result in reduced pain and improve function?
  • Focused ultrasound‐induced peripheral nerve modulation
  • Columbia University Sep 01, 2020 - Feb 28, 2022 Brain Program
    Clinical Trial Will FUS treatment of late stage cancer or mets to the pelvis be feasible, safe and initially effective?
  • HIFU-LATE Study: A Phase II feasibility/efficacy study of HIFU in late stage pelvic cancer
  • Imperial College Healthcare NHS Trust, St. Mary's Hospital Jul 28, 2020 - Jul 27, 2022 Research Award
    Technical Can a simplified, open-source GUI provide greater access to tractography-based targeting for the FUS community?
  • Development of a Clinically-Feasible Image Processing Platform for Diffusion MRI Tractography-Based Focused Ultrasound Targeting of Essential Tremor
  • Stanford University School of Medicine Jul 15, 2020 - Jan 14, 2021 Research Award
    Pre-Clinical Can sonodynamic therapy be used to treat cerebral cavernous malformations?
  • Focused Ultrasound Treatment of Cerebral Cavernous Malformations
  • University of Virginia Health System May 05, 2020 - May 05, 2021 Brain Program
    Pre-Clinical What is the optimal timing of FUS and immunotherapy treatment?
  • ImmunoPET imaging-based optimization of immunotherapy delivery to brain tumors with focused ultrasound
  • University of Virginia Health System May 01, 2020 - May 01, 2021 Immunotherapy
    Vet Can histotripsy safely treat osteosarcoma in dogs?
  • Histotripsy for treatment of canine appendicular osteosarcoma
  • Virginia-Maryland College of Veterinary Medicine Apr 20, 2020 - Apr 20, 2021 Veterinary
    Vet Can histotripsy safely treat soft tissue tumors in dogs?
  • Investigation of the immunostimulatory response to mechanical high intensity focused ultrasound (histotripsy) in dogs with naturally-occurring soft...
  • Virginia-Maryland College of Veterinary Medicine Apr 07, 2020 - Apr 07, 2021 Veterinary
    Pre-Clinical Which mechanical FUS mode is best at inducing a T-cell response in GBM?
  • Acoustic activation of the GBM-brain microenvironment for improved T-cell immunotherapy
  • University of Maryland School of Medicine Apr 01, 2020 - Apr 01, 2022 Immunotherapy
    Clinical Trial Will this neuronavigation device be able to safely and effectively open the BBB in AD patients?
  • Neuronavigation-guided focused ultrasound-induced blood-brain barrier opening in Alzheimer’s disease patients
  • Columbia University Mar 18, 2020 - Mar 17, 2021 Brain Program
    Pre-Clinical Can pulsed FUS promote stem cell therapy to treat acute kidney failure?
  • Priming The Injured Kidney With Pulsed Focused Ultrasound For Mesenchymal Stem Cell Therapy
  • Stanford University School of Medicine Feb 21, 2020 - Feb 20, 2021 Research Award
    Technical Can improved acoustic simulations of trans-skull treatments be used to better predict thermal rise and thus aide in improved patient selection?
  • Simulation of Transcranial Focused Ultrasound Propagation for Prediction of Thermal Lesions and Patient Selection
  • Inserm LabTAU Feb 18, 2020 - Feb 17, 2021 Brain Program
    Pre-Clinical Can FUS + immunotherapy treat ovarian and cervical cancer?
  • Activating specific cytotoxic T-cells by HIFU and systemic immunotherapy in treatment of recurrent ovarian and cervical cancer in a syngeneic animal...
  • Stanford University School of Medicine Jan 28, 2020 - Feb 01, 2021 Immunotherapy
    MOA Can FUS drug delivery be used to selectively deliver anesthetic agents for targeted pain management?
  • The Needle-less Nerve Block: Targeted Non-Invasive Analgesia with Ultrasonic Uncaging of Local Anesthetics
  • Stanford University School of Medicine Jan 23, 2020 - Apr 22, 2021 Research Award
    Vet Can FUS safely treat soft tissue tumors in dogs?
  • Investigation of the immunostimulatory response to high intensity focused ultrasound in dogs with naturally-occurring solid tumors.
  • Virginia-Maryland College of Veterinary Medicine Jan 01, 2020 - Jan 01, 2022 Veterinary
    Clinical Trial Will the use of FUS to pre-operatively partially treat patients with sarcoma produce an enhanced immune response?
  • Adjuvant Focused Ultrasound to Promote Immunotherapy Response for Undifferentiated Pleomorphic Sarcoma
  • University of California, San Francisco Nov 22, 2019 - May 21, 2022 Immunotherapy
    Pre-Clinical Is histotripsy a safe and effective FUS biomechanism for treating the pig pancreas, justifying the organization of a human clinical trial?
  • Development of Novel Porcine Models of Orthotopic Pancreatic Cancer for FUS and Histotripsy Tumor Ablation Applications
  • Virginia Polytechnic Institute and State University Nov 12, 2019 - Nov 11, 2020 Research Award
    Pre-Clinical Can histotripsy elicit a potent anti-tumor immune response in liver cancer?
  • Histotripsy tumor ablation-mediated immune-stimulation
  • University of Michigan Nov 06, 2019 - Nov 06, 2020 Immunotherapy
    Clinical Trial Will the FUS opening of the BBB prior to chemotherapy treatment in patients with breast cancer mets to their be feasible and safe?
  • A Study to Evaluate the Safety and Feasibility of Blood-Brain Barrier Disruption Using MRI-Guided Focused Ultrasound in the treatment of...
  • Sunnybrook Health Sciences Centre Oct 31, 2019 - Oct 30, 2021 Brain Program
    Clinical Trial Will using FUS to open the BBB in the area of the hippocampus in patients with AD improve their outcomes?
  • A Phase I/IIa Study: Feasibility of Blood-Brain Barrier Opening in the Hippocampus of Patients with Alzheimer’s Disease by MR-Guided Focused U...
  • Sunnybrook Health Sciences Centre Oct 30, 2019 - Oct 29, 2021 Brain Program
    Technical Can an encapsulated MR-active agent mitigate imaging artifacts to improve image-guidance for MRI-guided FUS?
  • Development of Novel Acoustic Coupling Media to Improve Image Guidance and Treatment Safety in Transcranial Focused Ultrasound Procedures
  • University of Virginia Health System Oct 24, 2019 - Jan 24, 2021 Research Award
    Technical Can 3D MRI thermometry be used to image the entire head in three seconds?
  • MRI Guidance of Focused Ultrasound Neurosurgery
  • University of Virginia Health System Oct 24, 2019 - Jan 24, 2022 Brain Program
    Technical Can skull temperature be monitored with MR  during treatment?
  • MRI of Skull Heating During Focused Ultrasound Neurosurgery
  • University of Virginia Health System Oct 24, 2019 - Jan 24, 2022 Brain Program
    Pre-Clinical Can FUS enhance the effectiveness of immunotherapies for breast and pancreatic cancer?
  • Focused ultrasound stimulation of the immune response in cancer models
  • Inserm LabTAU Oct 16, 2019 - Oct 16, 2020 Immunotherapy
    Pre-Clinical Can FUS enhance the efficacy of immunotherapeutics in a breast cancer model?
  • Focused ultrasound stimulation of the immune response in a breast cancer model
  • Inserm LabTAU Oct 16, 2019 - Oct 16, 2020 Immunotherapy
    Pre-Clinical Can histotripsy safely and precisely ablate brain tissue?
  • Transcranial Histotripsy for Treatment of Brain Tumors – Initial In-vivo Pig Study
  • University of Michigan Oct 01, 2019 - Sep 30, 2020 Brain Program
    Technical Is it possible to effectively treat temporal lobe epilepsy while avoiding adverse skull heating?
  • Investigating the Feasibility of Targeting Temporal Lobe using Transcranial MRI- Guided Focused Ultrasound
  • University of Maryland School of Medicine Sep 13, 2019 - Sep 12, 2020 Brain Program
    MOA Can laser-generated FUS - an alternate FUS technology - be used for BBB opening?
  • Blood Brain Barrier (BBB) Opening of Rat by Laser-generated Focused Ultrasound Transducer
  • Jeju National University Sep 10, 2019 - Mar 10, 2021 Brain Program
    Pre-Clinical Can FUS + immunotherapies control growth of pancreatic tumors?
  • aCD40 + ablation trial
  • Stanford University School of Medicine Sep 01, 2019 - Sep 01, 2020 Immunotherapy
    Vet Can FUS safely be used to treat oral tumors in dogs?
  • Treating veterinary cancer patients with focused ultrasound
  • Oklahoma State University Jun 01, 2019 - Jun 01, 2020 Veterinary
    Pre-Clinical Can FUS treat tumors in the collapsed lung?
  • Non-Invasive Surgical Treatment of Lung Cancer
  • University of Virginia Health System May 21, 2019 - Jul 20, 2020 Research Award
    Technical Can fast multi-slice MR thermometry increase safety, accuracy and clinical workflow efficiency while maintaining compatibility with current brain treatment workstation?
  • Remote Fellowship in MR Imaging for FUS Applications: Incoherent CAIPI Simultaneous Multislice Thermometry
  • University of Virginia Apr 01, 2019 - Aug 31, 2019 Brain Program
    Pre-Clinical Can FUS BBB aquaporumab delivery promote remyelination in a rat model of neuromyelitis optica?
  • FUS for therapy of Neuromyelitis Optica – an inflammatory demyelinating disease of the central nervous system
  • University of California, San Francisco Mar 25, 2019 - Mar 24, 2020 Research Award
    Pre-Clinical Can FUS + immunotherapeutics control pancreatic tumor growth in a mouse model?
  • Focused ultrasound immunomodulation for pancreatic cancer
  • University of Virginia Health System Mar 12, 2019 - Mar 12, 2020 Immunotherapy
    MOA Can microbubble concentration variations in the brain affect BBB opening with FUS?
  • Microbubble enhanced FUS treatments in the brain: impact of bubble distribution in a pig craniotomy model
  • University of Virginia Health System Mar 01, 2019 - Jan 22, 2020 Brain Program
    Technical Can a cross-platform (vendor agnostic) open-source skin cooling device be designed to facilitate thermal ablation close to the skin?
  • Convective skin-cooling device for use with existing MRgFUS systems to prevent skin burns
  • University of Utah Feb 28, 2019 - Nov 01, 2019 Research Award
    MOA Does microbubble concentration vary throughout the brain?
  • Microbubble distribution in the brain: a real-time intra-operative map to optimize FUS treatment
  • University of Virginia Health System Feb 21, 2019 - Jan 22, 2020 Brain Program
    Pre-Clinical Can FUS deliver gene therapies to reverse Parkinson's Disease?
  • MRGFUS GENE DELIVERY FOR NEUROPROTECTION IN PARKINSON'S DISEASE
  • Weill Cornell Medical Center
      Jan 18, 2019 - Jan 18, 2020 Brain Program
      Technical Can a standardized laboratory FUS system be designed that lowers the bar for entry to new labs and spurs the pace and quality of preclinical FUS research?
    • Development of a turnkey USgFUS preclinical research platform
    • Sonic Concepts, Inc. Jan 04, 2019 - Jan 03, 2020 Research Award
      MOA Can extracellular vesicles be designed and fabricated to facilitate FUS drug delivery?
    • Drug delivery strategies using drug-loaded extracellular vesicles generated by microbubble-assisted ultrasound
    • Universitair Medisch Centrum Utrecht Dec 11, 2018 - Dec 10, 2019 Research Award
      Technical Can a FUS compatible 3D MR Thermometry increase safety, accuracy and clinical workflow efficiency for brain treatments?
    • Remote Fellowship in MR Imaging for FUS Applications: Reduced-FOV MR Thermometry
    • University of Virginia Dec 01, 2018 - Feb 28, 2019 Brain Program
      Clinical Research Can functional-MRI imaging improve targeting and treatment outcomes in neurological FUS procedures?
    • Functional Neuroimaging Feedback for Focused Ultrasound Thalamotomy for Tremor Surgery
    • Ohio State University Sep 28, 2018 - Sep 27, 2019 Research Award
      Clinical Trial Does bilateral FUS ablative treatment of the anterior capsulotomy in patients with depression improve their outcomes?
    • A Phase 1 Trial of MR-guided Focused Ultrasound (MRgFUS) Bilateral Capsulotomy for the Treatment of Refractory Major Depressive Disorder (MDD)
    • Sunnybrook Health Sciences Centre Sep 27, 2018 - Sep 26, 2020 Brain Program
      Pre-Clinical What are the optimal histotripsy parameters to ablate cholangiocarcinoma tumors?
    • Non-invasive Focused Ultrasound Ablation for the Treatment of Cholangiocarcinoma Liver Tumors
    • Virginia Polytechnic Institute and State University Sep 13, 2018 - Aug 30, 2020 Research Award
      Pre-Clinical Can FUS ablation improve varicose vein in sheep as a precursor to clinical trials?
    • Non-invasive varicose vein treatment by HIFU under ultrasound guidance: Phase 1C – GLP preclinical investigation
    • Sep 13, 2018 - Sep 12, 2019 Research Award
      Technical Can a 3D thermometry MR sequence to improve FUS treatment efficiency and safety be developed?
    • Remote Fellowship in MR Imaging for FUS Applications: Volumetric Thermometry
    • University of Virginia Jul 20, 2018 - Oct 20, 2019 Brain Program
      Clinical Trial Does bilateral FUS ablation of the anterior capsule in patients with OCD improve their outcomes?
    • Phase I trial of MR-guided Focused Ultrasound (MRgFUS) bilateral capsulotomy for the treatment of refractory obsessive-compulsive disorder (OCD)
    • Sunnybrook Health Sciences Centre Jun 05, 2018 - Jun 04, 2020 Brain Program
      Pre-Clinical Does sonodynamic therapy cause damage to healthy brain tissue?
    • Safety study: sonodynamic therapy with 5-ALA in a porcine model
    • University of Virginia Health System Jun 05, 2018 - Jun 05, 2019 Brain Program
      Pre-Clinical Can irinotecan be safely delivered across the BBB with MRgFUS?
    • Safety evaluation of irinotecan delivery to a rat glioma model using a clinical MRI-guided system
    • Brigham and Women's Hospital Jun 04, 2018 - Oct 11, 2019 Research Award
      Clinical Trial Does ablative FUS therapy to the ANT disrupt the pathway for partial seizures becoming generalized?
    • Focused ultrasound thalamotomy for the prevention of secondary generalization in focal onset epilepsy
    • Ohio State University Jun 01, 2018 - May 31, 2018 Brain Program
      Pre-Clinical Can FUS + microbubbles mechanically destroy GBM vasculature?
    • Microvascular Ablation of Intracranial Gliomas with Focused Ultrasound (9L Line)
    • University of Virginia Health System
        Apr 24, 2018 - Apr 24, 2019 Brain Program
        Pre-Clinical Can FUS + microbubbles mechanically destroy GBM vasculature?
      • Microvascular Ablation of Intracranial Gliomas with Focused Ultrasound (F98 Line)
      • University of Virginia Health System
          Apr 06, 2018 - Apr 06, 2019 Brain Program
          Pre-Clinical Can FUS-mediated delivery of stem cells or mitochondria improve post-stroke outcomes?
        • Selective opening of the blood brain barrier using focused ultrasound combined with systemic delivery of neural progenitor cells and mitrochondria...
        • University of Virginia Health System Apr 04, 2018 - Sep 24, 2019 Brain Program
          Pre-Clinical Can FUS activate fluorescein to control GBM growth?
        • Sonodynamic therapy for treatment of C6 glioma in a rat model proof-of-concept study: Fluorescein
        • University of Virginia Health System Apr 04, 2018 - Jun 09, 2019 Brain Program
          Pre-Clinical Can sonondynamic therapy treat CCMs?
        • Focused ultrasound for treatment of deep-seated cerebral cavernous malformations
        • University of Virginia Health System Mar 26, 2018 - Sep 24, 2019 Brain Program
          Pre-Clinical Can FUS delivery of quinolinic acid in the brain disconnect epileptic foci from healthy brain?
        • Use of low-intensity focused ultrasound for the non-invasive, focal disconnection of brain circuitry in the treatment of neurological disorders
        • University of Virginia Health System Mar 18, 2018 - Jun 18, 2018 Research Award
          Pre-Clinical Can FUS consistently produce activation or repression of nerve cell activity?
        • Focused ultrasound mediated neuromodulation for the treatment of spinal cord injury pain
        • University of Maryland School of Medicine Mar 05, 2018 - Jun 14, 2019 Brain Program
          Vet Can FUS enhance drug delivery in dogs?
        • Investigation of focused ultrasound mediated enhancement of chronic non- healing wound antimicrobial therapy in client-owned dogs
        • Oklahoma State University Feb 12, 2018 - Sep 15, 2020 Veterinary
          Technical Can trans-cranial histotripsy or BBB opening be achieved with a low cost, optically driven transducer?
        • Laser-generated Focused Ultrasound Transducer for Transcranial Applications
        • Jeju National University Feb 08, 2018 - Apr 22, 2019 Brain Program
          Technical Can shock-wave FUS accelerate thermal ablation for large volume treatments?
        • Use of shock-wave exposures for accelerating thermal ablation of targeted tissue volumes
        • University of Washington Feb 07, 2018 - Apr 06, 2019 Research Award
          Pre-Clinical Can FUS deliver drugs across the urothelium (blood-urine barrier)?
        • Focused Ultrasound Mediated Drug Delivery across the Urothelium
        • Johns Hopkins University School of Medicine Feb 06, 2018 - Feb 05, 2019 Research Award
          Pre-Clinical Can nanoparticles that can be triggered by HIFU at varying time points - allowing sustained drug release in multiple "cycles" as in traditional chemotherapy - be developed?
        • Focused Ultrasound Driven Drug Release From Theranostic Nanoparticles For The treatment Of Pancreatic Cancer
        • Froedtert & the Medical College of Wisconsin Jan 24, 2018 - Jan 24, 2019 Research Award
          Clinical Research What proportion of treated lung cancer patients would have been candidates for one-lung flooding FUS ablation?
        • Accessibility and Benefit of FUS treatment for inoperable Lung Cancer Patients, a retrospective Analysis
        • SRH Wald-Klinikum Gera Dec 14, 2017 - Feb 13, 2019 Research Award
          Pre-Clinical Can FUS safely enhance the delivery of anti-amyloid antibodies in an Alzheimer's model?
        • Effects of FUS on CNS Uptake and Efficacy of an Anti-Amyloid Antibody in Aged Alzheimer’s Transgenic Mice - Cohort 2
        • Brigham and Women's Hospital Nov 30, 2017 - Mar 30, 2018 Research Award
          Technical Can acoustic reflections be used for trans-skull focal spot verification and visualization?
        • Acoustic Backscatter-based 3D Mapping of Cavitation and Skull Surface in Histotripsy Transcranial Applications
        • University of Michigan Oct 31, 2017 - Dec 31, 2018 Research Award
          Clinical Trial Will treatment of patients with chronic back pain with the FUSmobile device result in improved outcomes?
        • Safety and initial feasibility of using the Neurolyser XR device for the treatment of facet related low back pain
        • McGill University Sep 26, 2017 - Mar 25, 2019 Research Award
          Pre-Clinical Can FUS deliver adeno-associated virus (AAV) through the BBB to facilitate gene therapy in the brain?
        • MRgFUS Blood-Brain Barrier Drug Delivery with AAV2 Gene Therapy Microbubble Drug Conjugates
        • Sunnybrook Health Sciences Centre Sep 01, 2017 - Aug 31, 2018 Research Award
          Pre-Clinical Is FUS safe and effective at treating sacroiliac pain in pigs, and can a clinical study then be organized?
        • Safety and Effectiveness of Sacroiliac Joint Palliation in Swine using MRgFUS
        • University of California, San Francisco Jul 01, 2017 - Jun 30, 2018 Research Award
          Clinical Trial How does FUS treatment of patients with OO compare to the conventional therapy (radio frequency ablation)?
        • Comparative Study - FUS vs. RF ablation
        • University of California, San Francisco Jun 01, 2017 - May 31, 2020 Liver/Pancreas Program
          Pre-Clinical Can microbubble-enhanced focused ultrasound improve immune response in a glioma model?
        • Focused Ultrasound Immunomodulation in a Mouse GL261 Intracranial Glioma
        • Brigham and Women's Hospital May 17, 2017 - Jun 19, 2019 Immunotherapy
          Pre-Clinical Can FUS enhance the effectiveness of immunotherapies for metastatic melanoma?
        • Focused Ultrasound to Enhance Immunotherapy for Metastatic Brain Melanoma
        • Columbia University May 05, 2017 - May 05, 2019 Immunotherapy
          Pre-Clinical Can hyperthermia improve immune response in a glioma model?
        • Focused Ultrasound Immunomodulation in a Mouse GL261 Intracranial Glioma
        • Georgia Institute of Technology May 01, 2017 - Apr 02, 2018 Immunotherapy
          MOA Can FUS plus heat shock-responsive gene "switches" be used to drive targeted bone regrowth?
        • Patterning of bone regeneration via ultrasound activation of heat shock- responsive gene switches
        • University of Michigan Mar 01, 2017 - Feb 28, 2018 Research Award
          Clinical Trial Will unilateral treatment of the STN in patients with movement disorders from Parkinson's disease improve there outcomes?
        • A Prospective, Randomized, Sham Controlled Study to Evaluate the Safety and Efficacy of ExAblate Subthalamotomy for the Treatment of Parkinson’s D...
        • Centro Integral de Neurociencias HM Cinac Mar 01, 2017 - Sep 01, 2020 Brain Program
          Clinical Trial Will FUS ablation in children with benign central tumors improve there outcomes?
        • A Feasibility Safety Study Using the ExAblate 4000 system in Management of Benign Centrally-Located Intracranial Tumors Which Require Clinical...
        • Nicklaus Children's Hospital Feb 27, 2017 - Feb 26, 2019 Brain Program
          Technical Can MRI imaging be used in conjunction with (standard of care) CT to improve prediction of skull properties and improve trans-skull focusing?
        • Acoustic Parameters of Bone as a function of HU and MRI
        • Stanford University School of Medicine Feb 20, 2017 - Feb 21, 2018 Brain Program
          Clinical Trial Will the use of FUS to treat the bilateral thalamus improve the outcomes in patients with neuropathic pain?
        • Phase 1 Clinical Trial of MR Guided Focused Ultrasound (FUS) Thalamotomy of Central Lateral Thalamic Nucleus for the Treatment of Neuropathic Pain
        • University of Maryland School of Medicine Jan 19, 2017 - Jul 19, 2019 Brain Program
          Clinical Trial Can FUS safely, temporarily and repeatedly open the BBB in patients with AD?
        • A Study to Evaluate the Safety and Feasibility of Blood-Brain Barrier (BBB) Opening Using Transcranial MR-Guided Focused Ultrasound with Intravenous...
        • Sunnybrook Health Sciences Centre Jan 12, 2017 - Jan 11, 2019 Brain Program
          Technical Can MR be used in real time to monitor treatment induced tissue changes?​
        • Real-time Treatment Monitoring by Diffusion MRI
        • University of Virginia Health System Nov 29, 2016 - Nov 28, 2017 Brain Program
          Pre-Clinical Can thermal ablation improve immune response to a glioma model?
        • Focused Ultrasound Immunomodulation in a Mouse GL261 Intracranial Glioma
        • Sunnybrook Health Sciences Centre Nov 29, 2016 - Jun 17, 2019 Brain Program
          Pre-Clinical What are the optimal FUS exposure settings for inducing an immune response in a mouse model of breast cancer?
        • Ultrasound-induced immune response on breast cancer
        • University of Virginia Health System Nov 28, 2016 - Apr 09, 2020 Immunotherapy
          Pre-Clinical Can histotripsy improve immune response in glioma model?
        • Focused Ultrasound Immunomodulation in a Mouse GL261 Intracranial Glioma
        • University of Michigan Nov 07, 2016 - Jul 05, 2017 Brain Program
          MOA
        • FUS-mediated Neuromodulation from Unanesthetized Freely-moving Animals
        • Brigham and Women's Hospital Oct 01, 2016 - Sep 30, 2017 Research Award
          Pre-Clinical What is the immune response induced by FUS + CTLA4 in a pancreatic cancer model?
        • Defining Basic Properties of Physical Immunotherapy using HIFU and Immune Checkpoint Inhibition
        • Institute of Cancer Research Sep 07, 2016 - Jun 07, 2019 Immunotherapy
          Pre-Clinical Can FUS-mediated delivery of antibodies reduce buildup of alpha synuclein in the brain?
        • Antibody Delivery Through the BBB Opening in an Alpha-Synuclein Model
        • Columbia University Aug 15, 2016 - Feb 04, 2019 Brain Program
          Pre-Clinical Can pFUS/LOFU (LOw intensity Focused Ultrasound) improve immune response in a glioma model?
        • Focused Ultrasound Immunomodulation in a Mouse GL261 Intracranial Glioma
        • University of Maryland School of Medicine Aug 15, 2016 - Jun 08, 2017 Immunotherapy
          Technical
        • Massively Parallel Nonlinear Ultrasound Simulation of Histotripsy in the Brain
        • Michigan State University Jul 18, 2016 - Jul 18, 2017 Brain Program
          Vet Can FUS delivery of microRNA treat liver cancer in client owned dogs?
        • A novel genetic reprogramming therapy for hepatocellular carcinoma using focused ultrasound-guided delivery of microRNA
        • Stanford University School of Medicine Jul 01, 2016 - May 31, 2020 Veterinary
          Pre-Clinical
        • Ultrasound-mediated delivery of siRNA for enhancing temozolomide efficacy against glioblastoma
        • Boston University Jun 01, 2016 - Dec 15, 2017 Research Award
          Pre-Clinical
        • Minimally-Invasive Therapy for Parkinson’s Disease Achieved by the Focused Ultrasound-Targeted Delivery of Gene-Bearing Nanocarriers
        • Johns Hopkins University School of Medicine Feb 04, 2016 - Feb 03, 2017 Brain Program
          Pre-Clinical
        • Effects of FUS on CNS Uptake and Efficacy of an Anti-Amyloid Antibody in Aged Alzheimer's Transgenic Mice
        • Brigham and Women's Hospital Feb 01, 2016 - Jan 31, 2017 Brain Program
          Pre-Clinical Can priming the immune system improve the durability of the systemic effect obtained with ablation+immunotherapy in melanoma model?
        • Ultrasound ablation combined with immunotherapy: priming to enhance efficacy
        • University of California, Davis Feb 01, 2016 - Jan 31, 2017 Brain Program
          Technical
        • Development and Calibration of MR Techniques for In-Vivo Bone Thermometry
        • University of Virginia Health System Feb 01, 2016 - Aug 16, 2018 Brain Program
          Technical Can a 2-part (in- water and out-of-water) send/receive head coil be designed and safety tested for use with the Insightec brain transducers?
        • Neuro Focused Ultrasound MR Coil Fabrication and Testing
        • Stanford University School of Medicine Jan 06, 2016 - Apr 06, 2018 Brain Program
          Pre-Clinical
        • Evaluation of the Systemic Response to Boiling Histotripsy Treatment for Renal Carcinoma
        • University of Washington Dec 01, 2015 - Apr 30, 2017 Research Award
          Pre-Clinical
        • A Chronic Pig Study of Transcranial Histotripsy for Treatment of Brain Tumors
        • University of Virginia Health System Nov 11, 2015 - Dec 18, 2015 Brain Program
          Pre-Clinical What are the optimal FUS parameters for treating melanoma?
        • The Focused ultrasound mediated immune responses in metastatic melanoma
        • University of Virginia Health System Nov 01, 2015 - Sep 26, 2017 Brain Program
          Technical
        • Neuronavigation-guided and Ultrasound-Monitored Human BBB-opening Focused Ultrasound Prototype System
        • Columbia University Nov 01, 2015 - Oct 31, 2016 Brain Program
          Pre-Clinical
        • Transcranial Histotripsy for Treatment of Brain Tumors
        • University of Michigan Oct 21, 2015 - Feb 21, 2016 Brain Program
          Technical
        • Method for fully 3D volumetric thermometry, with application to transcranial MRgFUS of the brain
        • University of Utah Oct 09, 2015 - Oct 08, 2016 Brain Program
          Clinical Trial How does FUS treatment of patients with OO compare to the other conventional treatments?
        • Pediatric Focused Ultrasound Computational Data Center and Registry
        • Hospital for Sick Children Oct 01, 2015 - Dec 31, 2017 Research Award
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