Focused Ultrasound Therapy

Clinical Trials SquareFocused ultrasound is an early-stage, non-invasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with retained placenta. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue. Where the beams converge, the ultrasound produces precise ablation (thermal destruction of tissue) enabling retained placenta to be treated without surgery. While there have been some human treatments, further research is needed before this can become widely available.

The primary options for treatment of retained placenta include surgery.

For certain patients, focused ultrasound could provide a non-invasive alternative to surgery with less risk of complications and lower cost.

Advantages:

  • Focused ultrasound is non-invasive, so it does not carry added concerns like surgical wound healing or infection.
  • Focused ultrasound can reach the desired target without damaging surrounding tissue.
  • It can be repeated, if necessary.

Clinical Trials

At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of retained placenta.

Regulatory Approval and Reimbursement

Focused ultrasound treatment for retained placenta is not yet approved by regulatory bodies or covered by medical insurance companies.

Notable Papers

Jiang X, Tang Q, Yang B, Ye F, Cai L, Wang X, Luo X, Bu H. High-intensity focused ultrasound combined procedures treatment of retained placenta accreta with marked vascularity after abortion or delivery. Int J Hyperthermia. 2019 Mar 20:1-7. doi: 10.1080/02656736.2019.1581279.

Ye M, Yin Z, Xue M, Deng X. High-intensity focused ultrasound combined with hysteroscopic resection for the treatment of placenta accreta. BJOG. 2017 Aug;124 Suppl 3:71-77. doi: 10.1111/1471-0528.14743.

Caloone J, Huissoud C, Kocot A, Vincenot J, Dehay C, Giroud P, Misery P, Allias F, Rudigoz RC, Melodelima D. Non-invasive high-intensity focused ultrasound treatment of the placenta: a preliminary in-vivo study using a simian model. Ultrasound Obstet Gynecol. 2017 Nov;50(5):635-641. doi: 10.1002/uog.17350. Epub 2017 Oct 9.

Lee JS, Hong GY, Park BJ, Hwang H, Kim R, Kim TE. High-intensity focused ultrasound combined with hysteroscopic resection to treat retained placenta accreta. Obstet Gynecol Sci. 2016 Sep;59(5):421-5. doi: 10.5468/ogs.2016.59.5.421. Epub 2016 Sep 13.

Bai Y, Luo X, Li Q, Yin N, Fu X, Zhang H, Qi H. High-intensity focused ultrasound treatment of placenta accreta after vaginal delivery: a preliminary study. Ultrasound Obstet Gynecol. 2016 Apr;47(4):492-8. doi: 10.1002/uog.14867. Epub 2016 Mar 6.

Click here for additional references from PubMed.

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