Home Diseases and Conditions Premature Ovarian Insufficiency

Premature Ovarian Insufficiency

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Development Stage

Early Stage

Focused ultrasound research is in the laboratory phase and is not yet available for patients.

Clinical Trials

Focused ultrasound for this condition is being researched in clinical trials.

International Approval

Focused ultrasound is approved to treat this condition outside the US. Patients can seek commercial treatment at participating international sites.

FDA Approved

The US Food and Drug Administration has approved focus ultrasound for this condition. Patients can seek commercial treatment at participating sites.

Early Stage

Clinical Trials

International

FDA Approved

Focused ultrasound research for this condition is in the laboratory phase and is not yet available for patients.

Focused Ultrasound Therapy 

Focused ultrasound is a rapidly evolving, therapeutic technology that could transform the quality of life and decrease the cost of care for patients with premature ovarian insufficiency. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue. 

How it Works 

Where the beams converge, low intensity focused ultrasound treatment of the ovaries can increase the activation of the ovarian follicles in preclinical studies. This has been seen in a couple of preclinical models, but there is still much to be done before this technology will be widely available. 

The primary options for treatment of premature ovarian insufficiency are very limited, so this option would be an added help to those facing this condition.   

For certain patients, focused ultrasound could provide a welcome addition to conventional therapy.  

Advantages 

  • Focused ultrasound is non-invasive, so it does not carry added concerns like surgical wound healing or infection.  
  • Focused ultrasound can reach the desired target without damaging surrounding tissue. 
  • It can be repeated, if necessary. 

Clinical Trials 

At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of premature ovarian insufficiency.  

The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click here, it will take you to the latest information available from https://www.clinicaltrials.gov/.  

Regulatory Approval and Reimbursement  

Focused ultrasound treatment for premature ovarian insufficiency is not yet approved by regulatory bodies or covered by medical insurance companies. 

Notable Papers 

Xiao Y, Yang L, Wang Y, Wang Y, Chen Y, Lu W, Pei Z, Zhang R, Ye Y, Ji X, Liu S, Dong X, Xu Y, Feng Y. Pulsed Low-Intensity Focused Ultrasound (LIFU) Activation of Ovarian Follicles. IEEE Open J Eng Med Biol. 2024 Apr 26;5:316-329. doi: 10.1109/OJEMB.2024.3391939. eCollection 2024. PMID: 38766542  

Ling L, Hou J, Wang Y, Shu H, Huang Y. Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion-Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency. Cell Transplant. 2022 Jan-Dec;31:9636897221129171. doi: 10.1177/09636897221129171. PMID: 36282038  

Tang H, Liu Y, Fan Y, Li C. Therapeutic Effects of Low-Intensity Pulsed Ultrasound on Premature Ovarian Insufficiency. Ultrasound Med Biol. 2021 Aug;47(8):2377-2387. doi: 10.1016/j.ultrasmedbio.2021.04.022. Epub 2021 Jun 2.PMID: 34088530  

Click here for additional references from PubMed.