Focused Ultrasound Therapy
Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with glaucoma. This innovative technology focuses beams of ultrasound energy precisely and accurately on the ciliary body in the eye without damaging surrounding normal tissue.
The mechanism of action is that where the beams converge, the focused ultrasound produces precise coagulation of a portion of the ciliary body, which decreases the intraocular pressure by reducing the production of aqueous humor. The result is a non-incisional treatment of glaucoma. The procedure does need to be done in the operating room, as anesthesia is needed.
The primary options for treatment of glaucoma includes a variety of medications, trabeculoplasty or more extensive surgery that may include implantation of a foreign body into the eye.
For certain patients, focused ultrasound could provide a noninvasive alternative to conventional therapy with lower risk of complications and reduced cost.
- Focused ultrasound is noninvasive, so it does not carry added concerns like surgical wound healing, infection, or implantation of foreign bodies into the eye.
- Focused ultrasound can reach the desired target without damaging surrounding tissue.
- This treatment can be repeated, if necessary.
There are currently no focused ultrasound clinical trials recruiting patients with glaucoma.
Regulatory Approval and Reimbursement
The Eye Tech Care device has regulatory approvals for use in Europe, the Middle East, China, Latin America (Mexico), and multiple locations in South-East Asia (Malaysia, Singapore, Thailand, Philippines, Indonesia, and Vietnam).
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Marques RE, Ferreira NP, Sousa DC, Barata AD, Sens P, Marques-Neves C, Abegão Pinto L. High intensity focused ultrasound for glaucoma: 1-year results from a prospective pragmatic study. Eye (Lond). 2020 Apr 21. doi: 10.1038/s41433-020-0878-0.
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Rivero-Santana A, Pérez-Silguero D, Pérez-Silguero MA, Encinas-Pisa P. Pupil Ovalization and Accommodation Loss after High-intensity Focused Ultrasound Treatment for Glaucoma: A Case Report. J Curr Glaucoma Pract. 2019 May-Aug;13(2):77-78. doi: 10.5005/jp-journals-10078-1256.
Sousa DC, Ferreira NP, Marques-Neves C, Somers A, Vandewalle E, Stalmans I, Pinto LA. High-intensity Focused Ultrasound Cycloplasty: Analysis of Pupil Dynamics. J Curr Glaucoma Pract. 2018 Sep-Dec;12(3):102-106. doi: 10.5005/jp-journals-10028-1253.
Graber M, Rothschild PR, Khoueir Z, Bluwol E, Benhatchi N, Lachkar Y. High intensity focused ultrasound cyclodestruction versus cyclodiode treatment of refractory glaucoma: A retrospective comparative study. J Fr Ophtalmol. 2018 Sep;41(7):611-618. doi: 10.1016/j.jfo.2018.02.005. Epub 2018 Aug 20.
Giannaccare G, Vagge A, Sebastiani S, Urbini LE, Corazza P, Pellegrini M, Carmassi L, Bergamini F, Traverso CE, Campos EC. Ultrasound Cyclo-Plasty in Patients with Glaucoma: 1-Year Results from a Multicentre Prospective Study. Ophthalmic Res. 2018 May 16:1-6. doi: 10.1159/000487953.
Deb-Joardar N, Reddy KP. Application of high intensity focused ultrasound for treatment of open-angle glaucoma in Indian patients. Indian J Ophthalmol. 2018 Apr;66(4):517-523. doi: 10.4103/ijo.IJO_1024_17.
De Gregorio A, Pedrotti E, Stevan G, Montali M, Morselli S. Safety and efficacy of multiple cyclocoagulation of ciliary bodies by high-intensity focused ultrasound in patients with glaucoma. Graefes Arch Clin Exp Ophthalmol. 2017 Oct 17. doi: 10.1007/s00417-017-3817-4.
Graber M, Khoueir Z, Beauchet A, Benhatchi N, Hammoud S, Lachkar Y. High intensity focused ultrasound as first line treatment in patients with chronic angle closure glaucoma at risk for malignant glaucoma. J Fr Ophtalmol. 2017 Apr;40(4):264-269. doi: 10.1016/j.jfo.2016.10.013.
Mastropasqua R, Fasanella V, Mastropasqua A, Ciancaglini M, Agnifili L. High-Intensity Focused Ultrasound Circular Cyclocoagulation in Glaucoma: A Step Forward for Cyclodestruction? J Ophthalmol. 2017;2017:7136275. doi: 10.1155/2017/7136275. Epub 2017 Apr 22.
Graber M, Khoueir Z, Beauchet A, Benhatchi N, Hammoud S, Lachkar Y. High intensity focused ultrasound as first line treatment in patients with chronic angle closure glaucoma at risk for malignant glaucoma. J Fr Ophtalmol. 2017 Mar 22. pii: S0181-5512(17)30073-6. doi: 10.1016/j.jfo.2016.10.013.
Click here for additional references from PubMed.