Endometrial Tumors

Focused Ultrasound Therapy

Clinical Trials SquareFocused ultrasound is an early-stage, noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with endometrial tumors. This novel technology focuses beams of ultrasound energy precisely and accurately on targets in the body without damaging surrounding normal tissue. Where the beams converge, the ultrasound produces precise ablation (thermal destruction of tissue) enabling endometrial tumors to be treated without surgery.

The primary options for treatment of endometrial cancer include surgery, chemotherapy, radiation therapy, targeted treatments and combinations.

For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications and lower cost.


  • Focused ultrasound is a noninvasive treatment, without wound healing and infection concerns
  • Focused ultrasound can reach the desired target without damaging surrounding tissue.
  • Focused ultrasound can enhanced the chemotherapy dose for the target, with less impact to the rest of the patient.
  • It is repeatable, if needed.

Clinical Trials

There is a clinical trial in the UK assessing focused ultrasound to treat symptomatic (pain or bleeding) recurrent pelvic malignancy when conventional treatment options are not available. 

A second clinical trial in the UK is looking at recurrent gynecology cancers, including endometrial cancer. 

For a full list of endometrial cancer clinical trials, please see here.

Regulatory Approval and Reimbursement

Focused ultrasound treatment for endometrial cancer is not yet approved by regulatory bodies or covered by medical insurance companies.

Notable Papers

Guan L, Xu G. Destructive effect of HIFU on rabbit embedded endometrial carcinoma tissues and their vascularities. Oncotarget. 2017 Mar 21;8(12):19577-19591. doi: 10.18632/oncotarget.14751.

Sri T, Steren AJ, Stratton P. Endometrial Cancer: Hidden Pathology in a Patient with Abnormal Uterine Bleeding and Known Leiomyoma. Gynecol Obstet Invest. 2015;80(4):272-5. doi: 10.1159/000370002.

Agdi M, Tulandi T. Minimally invasive approach for myomectomy. Semin Reprod Med. 2010 May;28(3):228-34. doi: 10.1055/s-0030-1251479. Review.

Click here for additional references from PubMed.