- Last Updated: February 16, 2018
Colorectal cancer refers to cancers of the large intestine and rectum which usually begin as benign polyps that become cancerous over time. The exact cause of colorectal cancer is not known, but risk factors include age, family history, obesity, lack of exercise, diets high in red and processed meats, and heavy alcohol use. Individuals with a history of ulcerative colitis or Crohn’s disease are also at higher risk for colorectal cancer.
Colorectal cancer accounts for more than 142,000 new cases and 50,000 deaths annually. About 90% of all colorectal cancers occur in individuals older than 50 years.
Current TreatmentEarly stage cancers that are confined to the polyp can often be treated with colonoscopy or endoscopic mucosal resection. If the cancer has spread along or into the colonic wall, surgery can be performed to remove the polyps and explore the adjacent lymph nodes. A partial colectomy (removal of cancerous portion of the colon) can be performed in cases where the cancer has invaded the colonic wall.
Chemotherapy can shrink tumors before surgery or to mitigate the symptoms and spread of the cancer after surgery. It is often used in combination with radiation therapy. Targeted drug therapy can also be used in colorectal cancer.
Focused Ultrasound Therapy
Focused ultrasound could treat colorectal cancer by heating and destroying the tumor. Research efforts have been addressing several challenges, such as the thin colonic wall, air in the colon, and movements related to peristalsis (normal contractions and relaxations of the colon). However, there has been progress made on these issues, and there have been successful preclinical and volunteer studies. Clinical trials on humans with rectal cancer have been initiated.
A clinical trial is underway in Canada for the treatment of recurrent rectal carcinoma. This trial is only open to Canadian Citizens.
A clinical trial is underway in London, England looking at end stage rectal carcinoma that may be primary or recurrent. Patients must have exhausted all other treatments.
- To inquire about the study, please contact Paul D Abel (+44208 383 2268 or ) or Leonardo Monzon (+447932043627 or )
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