Focused Ultrasound Therapy
Focused ultrasound is an early-stage, noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with trigeminal neuralgia. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the brain without damaging surrounding normal tissue.
How it Works
Where the beams converge, focused ultrasound produces precise ablation (thermal destruction of tissue), which enables trigeminal neuralgia to be treated without surgery.
The primary options for treatment of trigeminal neuropathy include medication or invasive surgery.
For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications – such as surgical wound healing or infection – at a lower cost. It can reach the desired target without damaging surrounding tissue and is repeatable, if necessary.
A current clinical trial at the University of Maryland is treating patients with trigeminal neuralgia.
A current clinical trial at the University of Virginia is looking to treat patients with refractory chronic trigeminal neuropathic pain. Please note this study does not include treating trigeminal neuralgia.
See a full list of trigeminal neuralgia clinical trials.
See a list of treatment sites >
See a list of laboratory research sites >
Regulatory Approval and Reimbursement
Trigeminal neuralgia treatment in the US has not been approved by regulatory bodies or covered by medical insurance companies. In Europe, trigeminal neuralgia has been treated under the neuropathic pain CE Mark.
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Ma Y, Hsu G, Zhang F. The applicability and efficacy of magnetic resonance-guided high intensity focused ultrasound system in the treatment of primary trigeminal neuralgia. Med Hypotheses. 2020 Mar 25;139:109688. doi: 10.1016/j.mehy.2020.109688.
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Daniel Jeanmonod, Beat Werner, Anne Morel, Lars Michels, Eyal Zadicario, Gilat Schiff, Ernst Martin. Transcranial magnetic resonance imaging–guided focusedultrasound: noninvasive central lateral thalamotomy forchronic neuropathic pain. Neurosurg Focus. 2012 Jan;32(1):E1. doi: 10.3171/2011.10.FOCUS11248.
Michels L, Moazami-Goudarzi M, Jeanmonod D. Correlations between EEG and clinical outcome in chronic neuropathic pain: surgical effects and treatment resistance. Brain Imaging Behav. 2011 Dec;5(4):329-48. doi: 10.1007/s11682-011-9135-2.
Click here for additional references from PubMed.