Focused Ultrasound Therapy

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Focused ultrasound is an early-stage, non-invasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with tuberculosis. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue. Where the beams converge, the ultrasound produces precise ablation (thermal destruction of tissue) enabling tuberculosis to be treated without surgery. World-wide, tuberculosis is still a significant health problem. While significant work has been accomplished, there is still much to be done before this technology will be widely available.

The primary options for treatment of tuberculosis include medications, which are not completely effective.

For certain patients, focused ultrasound could provide a non-invasive alternative and perhaps more effective alternative to conventional therapy.

Advantages:

  • Focused ultrasound is noninvasive, so it does not carry added concerns like surgical wound healing or infection.
  • It can reach the desired target without damaging surrounding tissue.
  • It can be repeated, if necessary.

Clinical Trials

At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of tuberculosis.

Regulatory Approval and Reimbursement

Focused ultrasound treatment for tuberculosis is not yet approved by regulatory bodies or covered by medical insurance companies.

Notable Papers

Xie S, Cao H, Li J, Prasad Adhikari V, Yang M, Dong Y, Li D, Du Y. Bactericidal effects of high intensity focused ultrasound on Bacillus Calmette-Guerin in vivo and in vitro. Int J Hyperthermia. 2019;36(1):886-896. doi: 10.1080/02656736.2019.1649474.

Click here for additional references from PubMed.

 

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