Focused Ultrasound Therapy

Clinical Trials Square

Focused ultrasound is an early-stage, non-invasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with persistent allergic rhinitis. This novel technology focuses beams of ultrasonic energy precisely and accurately on targets nose without damaging surrounding normal tissue. Where the beams converge, the ultrasound produces precise ablation (thermal destruction of tissue) enabling persistent allergic rhinitis to be treated without surgery.

The primary options for treatment of persistent allergic rhinitis include medications. Surgery may be needed if medications are ineffective.

For certain patients, focused ultrasound could provide an alternative to medications or a non-invasive option compared to surgery.

Advantages:

  • Focused ultrasound is noninvasive, so it does not carry added concerns like surgical wound healing or infection.
  • Focused ultrasound is an efficient, outpatient treatment.
  • It can be repeated, if necessary.

Clinical Trials

At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of persistent allergic rhinitis.

Regulatory Approval and Reimbursement

Focused ultrasound treatment for rhinitis is not yet approved by regulatory bodies or covered by medical insurance companies.

Notable Papers

Zhong B, LiLK, Deng D, Du JT, Liu YF, Liu F, Liu SX. Effect of High-Intensity Focused Ultrasound Versus Plasma Radiofrequency Ablation on Recurrent Allergic Rhinitis. Med Sci Monit. 2019 Sep 9;25:6775-6781. doi: 10.12659/MSM.916228.

Feng GF, Han ZL, Wang F, Sun BC, Dai ZY, Yang SZ, Zhou CY. Comparison of high-intensity focused ultrasound therapy under nasal endoscopy guidance versus first-line drug treatment in patients with persistent allergic rhinitis. Genet Mol Res. 2015 Aug 19;14(3):9865-71. doi: 10.4238/2015.August.19.20.

Wei H, Shi L, Zhang J, Xia Y, Cuan J, Zhang Y, Li W, Yan A, Jiang X, Lang MF, Sun J. High-intensity focused ultrasound leads to histopathologic changes of the inferior turbinate mucosa with allergic inflammation. Ultrasound Med Biol. 2014 Oct;40(10):2425-30. doi: 10.1016/j.ultrasmedbio.2014.05.016. Epub 2014 Aug 15.

Wei H, Zhang Y, Shi L, Zhang J, Xia Y, Zang J, Yan A, Li W, Jiang X. Higher dosage of HIFU treatment may lead to higher and longer efficacy for moderate to severe perennial allergic rhinitis. Int J Med Sci. 2013 Nov 27;10(13):1914-20. doi: 10.7150/ijms.7117. eCollection 2013.

Click here for additional references from PubMed.

 

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