Keratoplasty

Background

arly Stage squareThere are numerous methods for correcting vision, ranging from external glasses, contact lenses to more invasive procedures such as Lasix. While these options offer improvements, the ideal system would be a correction to normal vision, which is completely non-invasive, safe and permanent. A method to reach this goal remains elusive.

Current Treatment

While lens capabilities are impressive, there remains the convenience factors for external lenses that impact the users. These range from the mechanical issues of constantly having glasses available, especially for those who only need the glasses for certain circumstances, such as reading, to those who use contact lenses, but cannot see well when they are removed. Lasix is closer to the ideal, but is only helpful for certain patients, and does include an incision. 

Focused Ultrasound 

One of the key things about focused ultrasound is that it is completely noninvasive. A preclinical study has shown that keratoplasty (surgery on the cornea) for presbyopia (farsightedness) can be accomplished with focused ultrasound that produced very good results. The conclusion was that focused ultrasound presents good biological safety for work on the eyes. More work needs to be done, but at the early stage it is very encouraging.

Notable Papers

Wang M, Li M, Yan P, Luo Q, Zhang Y, Du Z. The Effect of High Intensity Focused Ultrasound Keratoplasty on Rabbit Anterior Segment. J Ophthalmol. 2017;2017:6067890. doi: 10.1155/2017/6067890. Epub 2017 Feb 9.

Du Z, Yan P, Luo Q, Zhang D, Zhang Y. Keratorefractive Effect of High Intensity Focused Ultrasound Keratoplasty on Rabbit Eyes. J Ophthalmol. 2016;2016:5260531. doi: 10.1155/2016/5260531. Epub 2016 Jun 13.