Clinical Trials Square

Focused Ultrasound Therapy

Focused ultrasound is an early-stage, non-invasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with gastric tumors. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue. Where the beams converge, the ultrasound produces precise ablation (thermal destruction of tissue) enabling gastric tumors to be treated without surgery.

The primary options for treatment of gastric tumors invasive surgery or medications.

For certain patients, focused ultrasound could provide a non-invasive alternative to surgery with less risk of complications and lower cost.

Advantages:

  • Focused ultrasound is non-invasive, so it does not carry added concerns like surgical wound healing or infection.
  • Focused ultrasound can reach the desired target without damaging surrounding tissue.
  • It can be repeated, if needed

Clinical Trials

A clinical trial is recruiting patients with solid tumors with metastatic lesions, including gastric cancer, at the University of Virginia.

Regulatory Approval and Reimbursement

Focused ultrasound treatment for gastric tumors has not been approved by regulatory bodies or covered by medical insurance companies.

Notable Papers

Liu Z, Ran H, Wang Z, Zhou S, Wang Y. Targeted and pH-facilitated theranostic of orthotopic gastric cancer via phase-transformation doxorubicin-encapsulated nanoparticles enhanced by low-intensity focused ultrasound (LIFU) with reduced side effect. Int J Nanomedicine. 2019 Sep 18;14:7627-7642. doi: 10.2147/IJN.S212888. eCollection 2019.

Cheng CS, Chen L, Xie J, Chen Z. Multimodality palliative treatment with transarterial chemoembolization and high-intensity focused ultrasound for gastric leiomyosarcoma multiple liver metastasis pain: A case report. Medicine (Baltimore). 2019 Sep;98(39):e17328. doi: 10.1097/MD.0000000000017328.

Click here for additional references from PubMed.

 

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