2016 Symposium Oral Presentations

Abstracts and Video Recordings

Please note that some abstracts and/or videos have not been released by presenters for publication.

For poster abstracts, please download the PDF Program and Abstract Book.

 

Welcome; Honorary Presentations

       
 

Welcome and Opening Remarks. N. Kassell

      Video
 

Honorary President’s Address. J.W. Chang

     

Video

 

Ferenc Jolesz Memorial Award Presentation. N. McDannold

      Video
 

Movement Disorders — Clinical

       

BR-1

 

An international, randomized, controlled trial of Focused Ultrasound thalamotomy for essential tremor. W.J. Elias

  Abstract    Video

BR-2

 

Treatment of essential tremor and Parkinson’s disease tremor by MRI guided Focused Ultrasound: A report of 38 consecutive cases in a single center. M. Zaaroor

  Abstract    Video

YI-2

 

A randomized, sham-controlled trial of transcranial MR guided Focused Ultrasound thalamotomy trial for the treatment of tremor-dominant, idiopathic Parkinson’s disease. A. Bond

  Abstract    Video

BR-3

 

MRI guided high intensity Focused Ultrasound surgery for Parkinson’s disease. J.W. Chang

  Abstract     

BR-4

 

Focused Ultrasound likely dominates deep brain stimulation and stereotactic radiosurgery for medically-refractory essential tremor: An initial decision and cost-effectiveness analysis. J. Parker

  Abstract    Video

BR-5

 

Tractography-based VIM identification for Focused Ultrasound thalamotomy: Initial results. V. Krishna

  Abstract    Video
 

Panel Discussion: Movement Disorder | J.W. Chang, W.J. Elias, P. Fishman, V. Krishna, M. Zaaroor | Moderator: N. Kassell

      Video
 

Parkinson’s Disease — Pre-clinical

       

BR-6

 

Targeted delivery of brain-penetrating non-viral GDNF gene vectors to the striatum with MRI-guided Focused Ultrasound reverses neurodegeneration in a Parkinson’s disease model. B. Mead

  Abstract    Video

BR-7

 

Focused Ultrasound facilitated gene delivery for neuro-restoration in Parkinson’s disease mice. S. Wang

  Not released  
 

Alzheimer’s Disease

       

BR-8

 

MRI-g-FUS for the treatment of Alzheimer’s disease. K. Hynynen

  Abstract     

BR-9

 

Scanning Focused Ultrasound disruption of the Blood-Brain Barrier as an Alzheimer’s disease therapy. G. Leinenga

  Abstract     

BR-10

 

Scanning ultrasound as a treatment tool of proteinopathies including Alzheimer’s disease. J. Götz

  Abstract     

YI-5

 

Neurorestoration of the nigrostriatal pathway through multiple treatments with FUS-facilitated brain drug delivery. M. Karakatsani

  Abstract    Video
 

Psychosurgery; Epilepsy

       

BR-11

 

MRI guided high intensity Focused Ultrasound surgery for obsessive compulsive disorders. J.W. Chang

  Abstract    Video
 

Discussion: FUS for OCD. N. Lipsman

       Video

BR-54

 

Focused Ultrasound for Subcortical Epilepsy (FUSE). N. Fountain

       Video
 

Blood–Brain Barrier Opening

       

BR-12

 

Enhancement of FUS mediated delivery of stem cells to the brain. P. Fishman

  Abstract    Video

BR-13

 

Fluorescent lipid microbubbles for targeted brain drug delivery through the Focused Ultrasound-induced Blood-Brain Barrier opening in vivo. C. Sierra Sanchez

  Abstract    Video

BR-14

 

Ultrasound-mediated delivery of gadolinium and fluorescent–labelled liposomes through the Blood-Brain Barrier. M. Aryal

  Abstract    Video

BR-15

 

Sterile inflammatory response (SIR) in the brain following exposure to low intensity pulsed Focused Ultrasound and microbubble infusion. Z. Kovacs

  Abstract    Video

YI-7

 

Long-term effects of Blood–Brain Barrier opening with pulsed Focused Ultrasound and microbubbles. Z. Kovacs

  Abstract    Video

YI-4

 

Pulsed ultrasound non-destructively expands the extracellular and perivascular spaces of the brain. D. Hersh

  Abstract    Video
 

Brain — Technical

       

BR-16

 

Volumetric MR thermometry in a clinical transcranial MR guided Focused Ultrasound
system. H. Odéen

  Abstract     

BR-17

 

Multi-echo MR thermometry compared to single echo MR thermometry in the treatment of essential tremor. K. Butts Pauly

  Abstract    Video

BR-18

 

High-resolution whole-brain MR thermometry with a 3D EPI stack-of-stars pulse sequence. S. Jonathan

  Abstract    Video

BR-19

 

Ultrafast and sensitive volumetric passive acoustic mapping. C. Arvanitis

  Abstract    Video

BR-20

 

Tissue stiffness imaging with interleaved multiple-point MR-ARFI. D. Parker

  Abstract    Video

BR-21

 

Inside/outside the brain binary localization of cavitation activity based on harmonic content. G. Maimbourg

  Abstract    Video

BR-22

 

Inflection of temperature vs. power curve in tcMRgFUS: correlation with lesion location. K. Butts Pauly

  Abstract    Video

BR-23

 

MR-guided Focused Ultrasound on the pig brain tissue and its histology as a function of thermal dose. D. Paeng

  Abstract    Video

BR-24

 

Visualization tools for transcranial Focused Ultrasound procedure planning, simulation and analysis. J. Snell

  Abstract    Video

BR-25

 

HIFU for Pediatric Operations (HOPE) – A pediatric neurosurgical treatment system. T. Looi

  Abstract    Video
 

Panel Discussion: Brain Technology | K. Butts Pauly, C. Cain, K. Hynynen, D. Parker, E. Zadicario | Moderators: J. Aubry, J. Snell

       Video
 

Neuromodulation

       

BR-26

 

Simultaneous stimulation of the human primary and secondary somatosensory cortices using transcranial Focused Ultrasound. W. Lee

  Abstract    Video

BR-27

 

Transcranial Focused Ultrasound stimulation of the primary visual cortex in humans. W. Lee

  Abstract    Video

BR-28

 

Focused Ultrasound modulation of visual search performance and associated EEG in monkeys. C. Caskey

  Abstract     

BR-29

 

Ultrasound-mediated modulation of motor and ocular responses in anesthetized mice in vivo. C. Aurup

  Abstract    Video

BR-30

 

Non-invasive targeted delivery of GABA for neuromodulation: Evaluation by resting state functional MRI. N. Todd

  Abstract    Video
 

Future brain clinical applications. T. Meakem

       Video
 

Special Presentation: Cancer Moonshot

       
 

Update on Vice President Biden’s Cancer Moonshot Initiative. G. Simon

       Video
 

Brain Tumors

       

CA-1

 

Initial experience in a pilot study of Blood-Brain Barrier opening for chemo-drug delivery to brain tumors by MR-guided Focused Ultrasound. N. Lipsman

  Abstract    Video

CA-2

 

Enhanced bevacizumab delivery to the CNS by Focused Ultrasound induced Blood–Brain Barrier opening for malignant glioma treatment. H. Liu

  Abstract    Video

YI-3

 

MR image-guided delivery of non-viral miRNA-34a gene vectors via Focused Ultrasound inhibits tumor growth in a mouse glioma model. C. Curley

  Abstract    Video

CA-3

 

Closed-loop control of targeted drug delivery across the Blood-Brain Barrier in rat glioma models. T. Sun

  Abstract    Video

CA-4

 

MR-guided Focused Ultrasound for antibody delivery in a brain metastasis model. N. McDannold

  Abstract    Video

CA-5

 

Phase I/IIa clinical trial of Blood-Brain Barrier disruption by pulsed ultrasound. A. Carpentier

  Abstract    Video

CA-6

 

Preliminary report on sonodynamic therapy for C6 glioma rat model. Z. Xu

  Abstract    Video

CA-7

 

In vivo porcine histotripsy brain treatments. J. Sukovich

  Abstract    Video

CA-8

 

Neuronavigation-guided Focused Ultrasound and real-time acoustic mapping: evaluation in non-human primates with Blood-Brain Barrier opening. S. Wu

  Abstract     
 

Immunotherapy

       

CA-9

 

Definition of basic properties of physical immunotherapy in pancreatic cancer using HIFU and immune checkpoint inhibition. G. ter Haar

  Abstract     

CA-10

 

Melanoma growth control via ultrasound depends on the adaptive immune system and surpasses αPD-1. K. Timbie

  Abstract     

CA-11

 

Stress response of cancer cells after low intensity Focused Ultrasound. K. Skalina

  Abstract    Video

YI-8

 

Activatable nanodelivery combined with CpG-ODN and anti-PD-1 achieves a complete response in directly-treated and contralateral tumors in a murine breast cancer model. M. Silvestrini

  Abstract    Video

CA-12

 

The “ABSCOPAL” effect after USgHIFU treatment of advanced pancreatic cancer. F. Orsi

  Abstract    Video

CA-13

 

Characterizing the immune response to Boiling histotripsy ablation of renal carcinoma in the Eker rat. G. Schade

  Abstract    Video
 

Panel Discussion: Immunotherapy | K. Ferrara, C. Guha, F. Orsi, G. Schade, G. ter Haar | Moderator: T. Bullock

       Video
 

Liver/Pancreas — Technical

       

CA-14

 

Use of shock-wave exposures for accelerating thermal ablation of localized tissue volumes. V. Khokhlova

  Abstract    Video

CA-15

 

Effects of dosing and focal spacing in rapid ablation of large tissue volume using histotripsy with electronic focal steering. Z. Xu

  Abstract    Video

CA-16

 

The TRANS-FUSIMO system — towards a prototype for HIFU treatment of the liver under breathing motion. S. Haase and A. Melzer

  Abstract    Video

CA-17

 

Multifunctional robotic platform for USgFUS. A. Menciassi

  Abstract    Video

CA-18

 

Real time MR and US motion tracking for abdominal US/MRgFUS. J. Strehlow

  Abstract    Video

CA-19

 

Pancreatic tumor monitoring and treatment using Harmonic Motion Imaging for Focused Ultrasound (HMIFU) in a transgenic mouse model. T. Payen

  Abstract    Video

CA-20

 

Preliminary investigation of integrating deployable reflectors and fluid lenses with endoluminal ultrasound to enhance and dynamically adjust focal gain and depth. M. Adams

  Abstract     
 

Liver/Pancreas — Clinical

       

CA-21

 

Concurrent low dose Focused Ultrasound with chemotherapy in abdominal tumors. J. Vidal-Jove

  Abstract    Video

CA-22

 

Clinical experience of intra-operative High Intensity Focused Ultrasound in patients with colorectal liver metastases. Results of a Phase II study. D. Melodelima

  Abstract    Video

CA-23

 

[18F]-FDG PET and contrast MRI for enhanced guidance of Focused Ultrasound ablation in a syngeneic orthotopic model of murine pancreatic adenocarcinoma. S. Tucci

  Abstract    Video

YI-1

 

Endoluminal ultrasound applicators for thermal ablation of pancreatic cancer under MR-guidance: preliminary investigations in an in vivo porcine model. M. Adams

  Abstract     
 

Prostate

       

CA-33

 

High Intensity Focused Ultrasound in primary localized prostate cancer applicative evolution in 20 years of clinical practice. C. Chaussy

  Abstract    Video

CA-34

 

Local radical tumor ablation through combined transurethral resection and transrectal High Intensity Focused Ultrasound: A valid therapy to treat high risk prostate cancer. C. Chaussy

  Abstract    Video

CA-24

 

Early experience with HIFU in the United States at Vituro Health, Sarasota. S. Scionti

       Video

CA-25

 

MRI-guided transurethral ultrasound ablation (TULSA) of localized prostate cancer: 24-month follow-up of a prospective Phase I study. R. Chopra

  Abstract    Video

CA-26

 

Investigation of the therapeutic effects of pulsed Focused Ultrasound combined with encapsulated chemotherapeutic agents for treatment of prostate cancer in vivo. L. Chen

  Abstract    Video

CA-27

 

Monitoring histotripsy ablation with passive cavitation imaging. K. Bader

  Abstract    Video

CA-28

 

Real time tissue changes monitoring during the treatment of prostate cancer with HIFU. N. Sanghvi

  Abstract    Video

CA-31

 

Focal therapy with High Intensity Focused Ultrasound in low risk prostate cancer. C. Chaussy

  Abstract    Video

CA-29

 

MRI-US fusion guided High-intensity Focused Ultrasound with Focal-One® system: Impact on PSA, complications and genito-urinary functions during initial experience . A. Sivaraman

  Abstract    Video

CA-30

 

High Intensity Focused Ultrasound hemiablation versus MRI guided 'lesion only' ablation of prostate cancer — genito-urinary fuctional outcomes and complications. A. Sivaraman

  Abstract    Video

CA-76

 

Prostate cancer HIFU — Novelty or innovation?. J. Hu

  Abstract    Video
 

Bone Tumors

       

CA-35

 

Factors affecting the efficacy of the magnetic resonance guided Focused Ultrasound ablation for painful bone metastases: Results from a multicenter study in China. Q. Wang

  Abstract    Video

CA-36

 

Can MRgFUS achieve local control of bone metastases?. A. Bazzocchi

  Abstract    Video

CA-38

 

Effect of heating duration on therapeutic ratio in MR-HIFU hyperthermia mediated drug delivery using thermosensitive liposomes in rabbit Vx2 tumors. R. Staruch

  Abstract    Video

CA-39

 

Technical and imaging parameters predicting successful magnetic resonance guided Focused Ultrasound treatment of painful osseous metastases. P. Ghanouni

  Abstract    Video

CA-40

 

Technical aspects, feasibility, safety, and initial efficacy of osteoid osteoma ablation with MR guided High Intensity Focused Ultrasound. P. Yarmolenko

  Abstract     

CA-41

 

Bone thermal modelling for MRgFUS of osteoid osteoma – validation with human clinical data. A. Chisholm

  Abstract    Video

YI-6

 

Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS) treatment of osteoid osteoma: A prospective development study. M. Kimhy

  Abstract    Video

CA-42

 

Non-invasive therapy for osteoid osteoma: Double site, long term, prospective development study with MR guided Focalized Ultrasound. A. Napoli

  Abstract    Video

CA-43

 

MRI-guided High Intensity Focused Ultrasound treatment of osteoid osteoma in pediatric patients: Preliminary results. M. Temple

  Abstract    Video

CA-77

 

MR-HIFU ablation of oteoid osteoma: Experience in a pediatric tertiary care center. K. Sharma

  Abstract     
 

Breast Tumors

       

CA-44

 

Treatment of breast fibroadenoma with High Intensity Focused Ultrasound: Update of feasibility study IDE #G130252. C. Rochman

  Abstract    Video

CA-45

 

Long-term efficacy and tolerability of one or two US-guided HIFU treatment of breast fibroadenoma. R. Kovatcheva

  Abstract     

CA-46

 

High Intensity Focused Ultrasound in the treatment of breast fibroadenomata: Results of the HIFU-F trial. M. Douek

  Abstract    Video

CA-47

 

Harmonic motion imaging for characterization and Focused Ultrasound ablation monitoring of post-surgical human breast tumors. Y. Han

  Abstract    Video
 

Other Tumors

       

CA-48

 

MRgFUS for desmoid tumors within the thigh: Early clinical experiences. M. Bucknor

  Abstract    Video

CA-49

 

Anatomical distribution of pediatric sarcoma and neuroblastoma: Targetability with MR-HIFU. J. Shim

       Video

YI-9

 

Towards FUS lung cancer ablation: Aspects of MR guidance in flooded lung. F. Wolfram

  Abstract    Video

CA-50

 

A prospective study on the efficacy of single High Intensity Focused Ultrasound treatment of patients with benign symptomatic thyroid nodule. B. Lang

  Abstract     

CA-51

 

The effect of different treatment regimens with US-guided HIFU on thyroid nodule volume. R. Kovatcheva

  Abstract     
 

Drug Delivery for Cancer

       

DD-1

 

Ultrasound ablation enhances nanoparticle accumulation and survival in mammary carcinoma models. B. Fite

  Abstract    Video

DD-2

 

Targeted drug delivery with cyclodextrin-based nanocarriers and Focused Ultrasound triggering. D. Xu

  Abstract    Video

DD-3

 

Image guided liposomes for Focused Ultrasound assisted anticancer drug delivery. M. Thanou

  Abstract    Video

DD-4

 

Near infrared fluorescence imaging for Focused-Ultrasound mediated local drug delivery of doxorubicin. M. Thanou

  Abstract    Video

DD-5

 

Interleaved mapping of temperature and longitudinal relaxation rate monitor drug delivery from temperature sensitive liposomes during MR-HIFU induced hyperthermia. E. Kneepkens

       Video

DD-6

 

Vascular permeability changes following doxorubicin release from temperature sensitive liposomes are detected by dynamic contrast enhanced MRI. B. Fite

  Abstract    Video

DD-7

 

Ultrasound ablation transiently increases accumulation of small molecule gadoteridol within the ablated volume. B. Fite

  Abstract    Video
 

Cardiovascular

       

CV-1

 

Noninvasive thrombolysis using microtripsy in a porcine deep vein thrombosis model. Z. Xu

  Abstract    Video

CV-2

 

Acute blood pressure response during MRgFUS renal denervation in a normotensive rat model. A. Payne

  Abstract    Video

CV-3

 

Trans esophageal HIFU for cardiac ablation: First experiment in non-human primate. C. Lafon

  Abstract    Video

CV-4

 

Ex vivo and in vivo non-invasive ultrasound-based cardiac pacing. B. Quesson

  Abstract    Video

CV-5

 

Restoring perfusion after critical hindlimb ischemia using pulsed Focused Ultrasound and mesenchymal stem cell in aged mouse. J. Frank

  Abstract    Video

CV-6

 

A novel ultrasound guided therapeutic system for hypertension treatment. M. Gertner

  Abstract    Video
 

Keynote Event

       
 

John Grisham with Dr. Neal Kassell and CBS’s Chip Reid

       Video
 

Women’s Health/Gynecological

       

WH-1

 

Preservation of endometrium after Magnetic Resonance Imaging-guided High-Intensity Focused Ultrasound (MRI-HIFU) ablation for uterine fibroids of submucosal type. Y. Kim

  Abstract    Video

WH-2

 

Responses of uterine fibroids to gonadotropin-releasing hormone agonist (GnRHa) as a pretreatment of MR-guided High-Intensity Focused Ultrasound (MR-HIFU) ablation. Y. Kim

  Abstract    Video

WH-3

 

Targeted vessel ablation with MR-HIFU for the treatment of type 3 uterine fibroids. J. van Breugel

  Abstract    Video

WH-5

 

Portable ultrasound-guided High Intensity Focused Ultrasound with 3D electronic steering and targeting forecast function: 2-year prospective clinical trial for uterine fibroids. J.Y. Lee

       Video

WH-6

 

Preliminary clinical evaluation of Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS) combined with GnRH-a analog therapy in the treatment of diffuse adenomyosis. D. Zhang

  Abstract    Video

WH-4

 

A non-contrast method for evaluating non-perfused volume after MRgFUS treatment of uterine fibroids. S. Dababou, C. Marrocchio

  Abstract    Video
 

Musculoskeletal

       

MS-1

 

HIFU for targeted antibiotic delivery and therapy of chronic wounds and osteomyelitis. A. Ranjan

  Abstract    Video

MS-2

 

Effectiveness of MR-guided Focused Ultrasound treatment for the tender points in patients with painful bone metastasis or with chronic osteoarthritic pain. H. Namba

  Abstract    Video

MS-10

 

Effectiveness and safety of High Intensity Focused Ultrasound guided by Magnetic Resonance imaging (MRgFUS) in the treatment of osteoarticular lumbar spinal pain originating from the facet joints. Squarcia

  Abstract     
 

Ongoing and Future Musculoskeletal Clinical Work. Alberto Bazzocchi

     

Video

 

Emerging Applications

       

EA-1

 

Transcutaneous boiling histotripsy ablation of the kidney in an in vivoporcine model. V. Khokhlova

  Abstract    Video

EA-2

 

Pulsed Focused Ultrasound to kidneys induces molecular changes that potentiate mesenchymal stem cells to further improve acute kidney injury. S. Burks

  Abstract   

Video

EA-3

 

Use of focused beams of special structure for pushing and trapping kidney stones with acoustic radiation force. O. Sapozhnikov

  Abstract     

EA-4

 

Modulated Focused Ultrasound for treatment of de-myelinating axons in multiple sclerosis lesions — pilot animal studies. P. Mourad

  Abstract    Video

EA-5

 

Noninvasive peripheral nerve stimulation via Focused Ultrasound in vivo. M. Downs

  Abstract    Video

EA-6

 

The mechanosensitive TRPC1 channel is activated by pulsed Focused Ultrasound to induce stem cell homing. S. Burks

  Abstract    Video

EA-7

 

Low-intensity ultrasound prolongs lifetimes of transplanted mesenchymal stem cells. S. Burks

  Abstract     

EA-8

 

Red blood cells as ultrasound-triggered drug delivery vehicles: Activation via perfluorocarbon nanodroplets, targeting and photoacoustic imaging. A. Klibanov

  Abstract    Video
 

Technical Topics

       

TT-1

 

Passive acoustic mapping and MR thermometry for real-time multi-modality imaging of Focused Ultrasound ablation. C. Crake

  Abstract    Video

TT-2

 

Acoustic characterization of a clinical MR-guided HIFU system. S. Kothapalli

  Abstract    Video
 

Biomechanisms

        
 

Panel Discussion: Prominent Biomechanisms for the Future of Focused Ultrasound | T. Bullock, K. Ferrara, N. McDannold, C. Moonen, Z. Xu | Moderator: J. Foley

       Video
 

Collaboration and Data Sharing

       
 

Introduction to collaboration and data sharing. J. Foley

       Video
 

Special Lecture — Open science: Promise, progress, pitfalls. P. Bourne

      Video
 

The importance of collaboration in medical device development. R. Spekman

      Video
 

Lessons Learned

       
 

Panel Discussion: Lessons Learned from Successful Focused Ultrasound Sites | J. Cochran, P. Ghanouni, B. Lang, T. Łoziński, C. Robertson | Moderator: S. LeBlang

       Video
 

Lessons Learned, Development of MRgFUS Clinical Applications. P. Ghanouni

      Video
 

Development and Research Center of Noninvasive Therapies. Tomasz Łoziński

      Video
 

Harnessing the Full Potential of HIFU in Prostate Cancer Treatment. Cary Robertson

     

Video

 

Regulatory Science

       
 

Advancing medical device regulatory science throughout the total product life cycle. D. Bardot

       Video
 

Evidence Building

       
 

Panel Discussion: Evidence Building for Focused Ultrasound | T. Andreae, E. Blanc, M. Carol, M. Ferre | Moderator: R. Williams

       Video
 

Closing Remarks

       
 

Closing Remarks. N. Kassell

       Video