Focused Ultrasound Surgery Research Project Inventory
The following is a list of research sites currently engaged in pushing the frontier of this technology.
Barrow Neurological Institute
-
Thrombolysis in Acute Stroke Treatment with tPA and ultrasound
Breastopia Namba Hopsital, Miyazaki, Japan
-
MRgFUS clinical trials
o
Breast Cancer
o
Metastatic Bone Cancer
Brigham and Women's Hospital/Harvard Medical School
-
Focused Ultrasound
Laboratory
The National Center for Image Guided Therapy
-
Ultrasound Therapy Delivery Through Intact Skull
-
Biological effects of ultrasound
o
Sonoporation
o
Mechanisms of ultrasound-induced apoptosis
o
Mechanisms and applications of porphyrin-induced sonodynamic
effect
o
Ultrasound enhanced glomerular filtration rate of kidney
o
Targeted Drug Delivery to the Brain by MRgFUS
o
Immunoelectron microscopic investigation of tight junctional
proteins after ultrasound-evoked opening of the blood-brain barrier
-
MR Guided Focused Ultrasound Surgery
o
Optimizing the MRI scan parameters for thermal therapies
o
Developing MRI-compatible treatment devices
o
Demonstrating the feasibility of targeting the ultrasound beam
with temperature-sensitive MRI and of predicting the tissue damage with thermal
dosimetry
o
Developing new MRI sequences that can be used to overcome the
current limitations of MRI thermometry (imaging in fatty tissues, improving the
motion sensitivity)
o
Using rapid MRI to control online the power deposition
o
Using the sequences during tumor treatments
-
Ultrasound Shear Mode Transcranial Ultrasound imaging
-
Intraoperative monitoring
-
Microbubble interactions
-
MRgFUS clinical trials
o
Brain tumors
Chaim Sheba Medical Center, Israel
-
MRgFUS
clinical trials
o
Uterine fibroids
o
Bone metastasis
o
Liver tumors
Cornell University
-
MRgFUS clinical trials
o
Uterine Fibroids
o
MRgFUS
research
-
Uterine Fibroids
-
Breast Fibroadenoma
-
Breast Cancer
Charite Hospital, Berlin
-
MRgRUS clinical trials
o
Uterine Fibroids
o
Liver tumors
o
Metastatic bone cancer
Duke University
-
HIFU
for prostate cancer - clinical trial with EDAP Ablatherm device
-
HIFU for breast cancer
and gene therapy
-
High
Intensity Focused Ultrasound induced Gene Activation in Solid Tumors
-
Cary
N. Robertson, MD, FACS - HIFU prostate cancer treatment
Isei Kai Hospital, Osaka, Japan
-
MRgFUS clinical trials
o
Uterine fibroids
Lahey Clinic
-
MRgFUS clinical trials
o
Uterine Fibroids
-
MRgFUS Research
o
Prostate
o
Gynecologic tumors
o
Gastrointestinal cancers
Mayo Clinic
-
Magnetic
Resonance Laboratory
o
MRI Guided Focused Ultrasound Ablation
§
Feasibility evaluation
§
Surface lesion ablation
§
Thermal and non-thermal ablation monitoring techniques
Methodist Hospital, Houston, Texas
-
Pulsed HIFU facilitated drug delivery and control
Mt. Sinai Hospital, Toronto
-
MRgFUS clinical trials
o
Bone metastasis
National Institutes of Health
-
Molecular imaging input
-
Drug delivery
-
HIFU physics - pulsed HIFU
-
MR physics
-
Histology
-
Animal models
-
Drug/device combinations
Stanford University
-
Bioengineering
o
Micro-Electical-Mechanical (MEMS) transducer devices
-
Radiological
Sciences Laboratory
o
FUS Ablation of Prostate
o
FUS Ablation of Liver
o
Motion Correction for MR Thermometry
-
Thermal
Therapy Research Group
o
Design & Development of Ultrasound Devices
o
Targeted Hyperthermia
o
High-temperature Thermal Therapy
St. Mary's Hospital/Imperial College, London
-
MRgFUS
clinical trials
o
Uterine Fibroids
o
Liver tumor
o
Metastatic bone tumors
University Children's Hospital Zurich
-
Functional
Neurosurgery
o
Parkinson's disease
o
Dystonia and tremors
o
Neurogenic pain
o
Tinnitums
o
Neuropsychiatric disorders
o
Epilepsy
-
Functional
neurosurgical planning for tcMRgFUS
o
Theoretical modeling of thalamocortical dysrhythmia
o
Application of the Morel Atlas for target volume planning in
functional neurosurgery
o
Validation of the TcMRgFUS technology and clinical application in
fuctional neurosurgery
University of California San Diego, San Diego, CA
-
MRgFUS clinical trials
o
Bone metastasis
o
Uterine Fibroids
University of Michigan
-
Basic Radiological
Sciences Ultrasound Group
o
Acoustic droplet vaporization
o
Reversable vascular occlusion with FUS and droplet vaporization
o
Enhancement of therapeutic US with droplet vaporization
o
Microbubbles as point source targets for phase correction of FUS
transducers
o
FUS Histotrypsy - liquefaction of tissue via FUS and microbubbles
without heating
o
Bioeffects and safety of US
University of Tokyo, Japan
-
Non-invasive
treatment of tumors utilizing microbubbles
-
Development
of a microbubble-enhanced ultrasound gene transfer system
University of Toronto
-
HIFU
o
Noninvasive surgery
o
Vascular surgery
o
Targeted drug delivery
o
Gene therapy
o
Theoretical modeling
o
Transducer design
University of Utah
-
Laboratory
of Ultrasonic Drug Delivery
o
Targetable drug delivery systems to treat drug sensitive and drug
resistant solid tumor carcinomas triggered by ultrasoundEdwin A. Stevens, M.D.
Chairman,
-
Dept. Radiology/Utah Center for
Advanced Imaging Research
o
Automated
treatment plan execution with feedback for MRgFUS
University of Washington
-
The Center for Industrial and
Medical Ultrasound
o
Accoustic Hemostasis
o
Ultrasound-guided HIFU
o
Ultrasound-enhanced drug delivery
o
Physics of ultrasound contrast
o
Ultrasound Contrast Agents
o
HIFU Arrays
o
Neurolysis for Spasticity and Pain
o
Tissue-mimicking phantoms for ultrasound therapy
o
Acoustic coupling for therapeutic ultrasound
o
Intra-operative acoustic hemostasis
o
Image-guided treatement of uterine tumors with HIFU
o
Accoustic hemostasis for advanced trauma care
