FUSF Funded Research Projects
Tests of microbubble-enhanced ablation in a large animal model with a low-frequency, transcranial MR
Principal Investigator: Nathan McDannold, Ph.D., Associate Professor, Department of Biology, Brigham & Women's Hospital
Co-Investigator: Margaret Livingstone, Ph.D., Professor, Department of Neurobiology, Harvard Medical School
Funding Period: October1, 2011 – September 30, 2012
Abstract: This study will test transcranial microbubble-enhanced thermal ablation in the brain in a large animal model using a low-frequency transcranial MR-guided focused ultrasound system. We aim to show that this ablation does not damage non-targeted areas or cause delayed effects. We will also measure cavitation thresholds and examine the ablation in MRI and histology. This ablation method has the potential to increase the regions in the brain that can be targeted by focused ultrasound, but safety concerns need to be addressed using a realistic animal model.