FUSF Funded Research Projects
Targeted Delivery of Controlled-Release Nanoparticles to Brain Tumors Using Contrast Agent Microbubbles and High-Intensity Focused Ultrasound
Principal Investigator: Richard Price, Ph.D., University of Virginia, Department of Biomedical Engineering
Co-Investigator: Jason Sheehan, M.D., Ph.D., University of Virginia, Department of Neurosurgery
Funding Period: September 1, 2007 - August 31, 2008
Abstract: High-Intensity Focused Ultrasound (HIFU) treatment of brain tumors is complicated by heating of the skull. Here, our goal is to overcome this limitation by developing an ultrasound-microbubble-based therapeutic approach that complements HIFU by mechanically-damaging tumor tissue, occluding blood flow, and depositing 5-FU bearing controlled-release nanoparticles into brain tumors at reduced power levels. Experiments for monitoring nanoparticle delivery, blood flow changes, and tumor regression will be performed using tumors implanted in mouse dorsal skinfold window chambers. We anticipate these that studies will result in the successful development of a delivery method and agent(s) suitable for preclinical testing with HIFU.
Progress Report: Final progress report